PTH eketsehileng - e leng se pakoang ke and analysis joang?

Parathyroid hormona (ho seng joalo e bitswang parathyroid hormone, parathyrin) - e-hormone tse hlahisoang ke ho parathyroid litsoelesa dinama tse nyenyane tse (parathyroid), tse teng ka lehlakoreng anterolateral ea molaleng. Ba ka mor'a thyroid tsoelesa e, e leng ke haufi-ufi le haufi le holim 'morao lona le karolong e ka tlaase ea bobeli bolelelane lona. Parathyroid hormona tsa tlhaho tsa bona lik'hemik'hale ke rarahaneng protheine ntho - polypeptide amino derivatives acid e.

mosebetsi lona ka sehloohong ke ho ba le seabo le molao oa tsamaiso ea khalsiamo le phosphorus metabolism 'meleng. The dikahare tsa k'halsiamo ka mali le secretion ea li-hormone parathyroid ke ka ho toba e itšetlehileng ka ho ba bang. Hormone ka eketsa k'halsiamo mahloriso ka ho etsa lintho ka lesapo dinama tse nyenyane tse, a liphio le pampitšana gastrointestinal. The lesapo parathyrin eketsa logoff dissolving karolong matsoai ka Stimulating tswakana tsa enzyme e itseng hore ba na le boikarabelo bakeng sa ho sithabela ha boitsebiso masapo. Bone dinama tse nyenyane tse e tlas'a tlas'a tšusumetso ea PTH resorption le k'halsiamo ions ba sebakeng mali. Hammoho le k'halsiamo phapanyetsano paratgormot thusa ho laola ho boemong ba phosphate 'meleng. Fokotsa matla a tshebetso pele likokoana-hloko, ho amplifies phalla bobeli. Ho feta moo, li-hormone e amehang ho matlafatsa tswakana tsa calcitriol ka intestine, ho thusa k'halsiamo reabsorption. Parathyroid hormona nka e le karolo ea sa tobang ka molao oa tsamaiso ea mesebetsi ea tsohle enzyme k'halsiamo-itšetlehileng ka katalirizuemye itsoara joang ka bona. Tlas'a tšusumetso ea hae hape o fumana tsamaiso mali coagulation.

Ha PTH e phahameng, ka nako eo ha thehoa mafu haholo endocrine amanang le lesapo botšepehi ba tlōla - hyperparathyroidism, le osteoporosis. Phello ea joalo sekoli fisioloji sharply decreases ka maemo k'halsiamo mali, e leng isang ea eketseha neuromuscular excitability. Comorbidities tabeng ena ka sebeletsa phahameng a alkali dikahare 'meleng le ntshetsopele ya ho hloleha renal. Ka ho fokotsa diteng tsa khalsiamo ka lense mahlo cataract se hlahile.

Maemo a ka li-hormone tsa litsoelesa parathyroid maling e ka tlasa ho morethetho circadian. Boemo basal e behiloeng ka ka ka 8 hoseng, ha a ntse a ka lihora tse 14-16 ea letsatsi, ha motho a e ka tlhōrō ea mosebetsi, parathyroid hormona eketseha. teko ea mali o etsoang tsoa ka palo ea parathyrin immunohemilyuminestsentsii. E lokela ho etsa mala se nang letho, le letsatsi kapa a mabeli pele ho mali mohlala felisa joala ho noa le ho ikoetlisa boima bakeng sa lihora tse 'maloa pele ho buuoa, le se ke ka tsuba.

Ka ho hlahloba hormona parathyroid e hlophisitsweng feela ha ho e-ba le mamello e belaela boteng ba mafu a kang hyper- le gipokaltsimiya, urolithiasis le neurofibromatosis. Hape ho bonahala ka morero and analysis ka kenyelletsa: osteoporosis psevdoperelomy masapo telele, fisioloji efe kapa efe e fetola lesapo osteosclerosis kapa 'mele vertebral le belaela multiple endocrine neoplasia mofuta 1 le mofuta 2 (BATHO 1.2). Ka sekhahla parathormone bakeng sa motho e moholo ho nkoa 9,5-75 pg / ml tse. Hona ho sebetsa ho banna ba bobeli le basali ba lilemo ho ikatisa. Ha lemoha hore PTH e phahameng, ho na le mabaka a utloahalang ho nahana hore ho ba le mamello e na le ka sehloohong, se mahareng, e phahameng hyperparathyroidism, pseudohypoparathyreosis kapa lefu Zollinger-Ellison.

Tlasa kopantswe mathomo hyperparathyroidism hyperplasia tsa tšoelesa parathyroid, kankere ea tšoelesa ea senya lisele le endocrine neoplasia mefuta e 'meli. Co. mahareng hyperparathyroidism kenyeletsa foleng renal insufficiency, hypervitaminosis D, ulcerative colitis, rickets, lefu Crohn e. Ha PTH e phahameng, moo and analysis e hangata etswa ka kopanelo le tlhaloso ya boemong ba k'halsiamo maling le nakong e tlang ho bapisa litsupa tse peli le ho hlokomela dependencies.