"Pipekuroniyu lethal gene": litaelo tsa tšebeliso

Meriana phomotse mesifa ya marapo, ba ho pharaletseng sebediswa eseng feela ka nako ya mekgwa ya tshebetso ho buoa e hlolang ka nako e mahareng le ho nako e telele, empa hape le mokhoa oa ho ho sithabela ka sepheo sa ho repositioning kapa manonyeletso prosthetic. "Pipekuroniyu lethal gene" le bolela sehlopha se antidepolyarizuyuschih relaxants le na le nako palo e kahodimodimo ea nkang khato ea ho metsotso e 50-70 ho itšetlehile ka litšobotsi tsa phelang. A re hlahlobeng litaelo bakeng sa tshebediso ya lithethefatsi, 'me haholo-holo e sebelisa ka ikwetlisetse thethefatsa.

diokobatsi characterization

The mochine ea nkang khato ea lithethefatsi amanang le thibela phetiso synaptic ka synapse neuromuscular. Ka lebaka la sena, ho na le thibelo ea ketsahalo e sa le monyetla oa ho nka khato ka lera mesifa faeba, 'me kahoo, e mesifa seleng ea lahleheloang matla a ho konteraka.

Le ho pepesehela ka nako e telele ho ea lithethefatsi tlas'a maemo "pipekuroniyu lethal gene" ya marapo musculature relaxes. Fuoa hore nicotinic cholinergic receptors tsa mofuta o le teng, eseng feela ka ho ikopanye le sebaka sa likhoele efferent somatic tsamaiso ea methapo le lisele tsa mesifa ea mesifa ya marapo le ganglia ka tsamaiso ea methapo autonomic, ho qaloa ho tekanyetso e khōlō ea moriana o ile a etsa hore e le hantle ganglioblokiruyuschimi fokola. Sena ke ka ntlha ya go ho cessation ea phetiso tšusumetso e tsoang ho methapo ea kutlo ho lera la postsynaptic tsa methapo ea kutlo, eo e etsa hore ea fokotseha ka litla bobeli le kutloelo-bohloko le parasympathetic.

ho bonahala

Ho lokisetsa "pipekuroniyu lethal gene" e bontša bakeng sa boikhathollo ba mesifa ya marapo nakong buuoa. Katleho ea lithethefatsi bakeng sa ho tracheal intubation le ventilation phetha molao feela.

Contraindications

E le lithethefatsi ho "pipekuroniyu lethal gene" taeo, lithethefatsi e feletseng contraindicated ka ho ba teng ha hypersensitivity le ka ho ba teng ha myasthenia (seoelo, liphatsa tsa lefutso ikemiselitse lefu, e leng ka ho tlōla nyakallo le ho ntshetsopele neuromuscular synapse le bofokoli mesifa).

moriana o contraindicated bakuli ka mekhahlelo ea pele ea bokhachane. Ka mekhahlelo e hamorao ba lithethefatsi ba ka 'na sebelisoa, joalokaha ho lifapano le mokoallo placental ka tekanyo e nyenyane.

litla-morao

Lithethefatsi ka thibela metsoako mosebetsi oa tsamaiso ea methapo e bohareng, etsang hore hypersensitivity liketsahalo.

From lehlakoreng la litla pelo lehlakoreng bakoang ke thibelo ea phetiso ea cholinergic ka synapses ena. Ho etsa joalo ho ka 'na fokotsa lebelo leo pelo, khatello ea mali e tlase, ischemic myocardial mo ntša kotsi, boko tshenyo amanang le fokotseha perfusion.

Ha o ile a pepesa ho khoneha ho tepella maikutlo ea tsamaiso ea ho hema tsa mosebetsi ho hema, e leng ketsahalo e sa apnea kapa apnea (haholo-holo ka nako ya aftereffects ya moriana).

Lithethefatsi ama metabolism 'me le khona ho etsa hore ho eketseha ha boemo ba mali potassium, ho eketsa boemo ba e se nang sesosa creatinine le maemo ka tlaase lero la mali tsoekere.

Lithethefatsi "pipekuroniyu lethal gene" - litaelo tsa tšebeliso

moriana o laolwa feela tlas'a bookameli ba setsebi sa. Pele tsamaiso ea lithethefatsi lokela ho hlahloba boteng ba anticholinesterases ( "Neostegmina" kapa "Pyridostigmine") kapa anticholinergics ( "Atropine").

Ka mor'a hore mellwane e tsoelang pele le mamello boalosi e atlehe nakong hlaphoheloa ka mor'a thethebatso le mamello ho normalize mesifa molumo.

The litekanyetso li behoa ea moriana o ka lebaka la ho hlahloba ka rarahaneng tsa mamello le ya data ho etsa lipatlisiso dithekeniki and analysis laboratoring. Ka ho ba teng ha ho hlōleha ha renal excretory mosebetsi, mesebetsing hloleha sebete, botenya - lethal dose lokela ho ba ka tlaase moriana o.

tharollo e lokisetsa hang-hang pele ho tsamaiso ea lithethefatsi "pipekuroniyu lethal gene." Foromo ya lithethefatsi ho lokolloa - vials tsa phofo lyophilized nang 0.004 g, tsa boleng bo sebetsang.

Bakeng sa bakuli ba nang le bokooa mali a electrolyte ho leka-lekana 'me ho leka-lekana acid e-botlaaseng ho boetse ho hlokahala phetoho e lethal dose. Khethehileng phokotso ea mahloriso Ion ka lero la mali mali, hypothermia le tšebeliso ea glycosides cardiac (nakong digitalization) ba khona ho lelefatsa ea nako ea lithethefatsi. Tabeng ea boikhathollo mesifa sehlopheng sena bakuli qalong lokela ho normalize le electrolyte mali, 'me joale ho phetha mesifa boikhathollo. Tabeng ea bakuli ba ho hloleha foleng pelo, ajoa mali a ka a liehe e katoloso ea nako latent tsa ama batho lithethefatsi (eketseha nako eo pakeng tsa tsamaiso le qala ho ea le phello).

O ka sebelisa lithethefatsi bana ho tloha 1 selemo. Tabeng ena e lokela ho a hopola hore 'mele oa ngoana ea ka tlaase nahanela liphello tsa mesifa e phutholohe,' me ka lebaka leo, ho fihlela e le hantle li lakalitseng, le lethal dose ea lithethefatsi lokela ho ea eketseha.

phomolong ea lithethefatsi

Ho laela lithethefatsi bakeng sa "pipekuroniyu lethal gene" risepe ka Latin ke ke esita le ho ba teng le ngaka. setheo Medical fumana dintho tse matla ho tloha lethathamo A feela ka kopo e le ka lebaka la mmuso. Ka nyeoe e 'ngoe, "pipekuroniyu lethal gene" risepe ka' na tsa fana ka setsebi sebedisa "bofubelu" foromo, Leha ho le joalo, hase bohle ba marangrang sepetlele ba tlamehile ho ho phethahala ha lithethefatsi le lithethefatsi ka thata, ho kenyeletsa relaxants mesifa.

mabitso a kgwebo ya

Ka 'marakeng meriana le lithethefatsi fumaneha tlasa mabitso a kang khoebo ea ka "Arduan" "Vero pipekuroniyu", "Aperamid", "pipekuroniyu lethal gene." Trade lebitso la ea lithethefatsi ke e itšetlehileng ka moetsi, fa e le lithethefatsi ho 'marakeng meriana.

overdose

E overdose ea lithethefatsi le phello phokotsong ka etsahala ka lebaka la matseno anticholinesterases. lithethefatsi tsena li ka thusa ho eketsa ea mahloriso tsa neurotransmitter acetylcholine, ka tsela eo gaisana mo le mesifa e phutholohe tsa libaka ka receptor e tlamang.

Hape, mehato phekola ka overdose etselitsoe ho eketsa khatello ea mali, ho boloka mesebetsi ea bohlokoa 'mele, ho akarelletsa le ka ho qhekella ventilation phetha molao feela.

ditshebeditsano lithethefatsi

moriana ke ke tsoakane le ditharollo fapaneng Infusion, haese ditharollo isotonic tsa sodium chloride le dextrose. Ntshetsopeleng ya e le hantle ea lithethefatsi liehisa, e atlehang ho phekola lethal dose e eketsehileng tlas'a boemo ba tsamaiso preoperative ho mokuli ea inhibitors cholinesterase.

Ka kopo e kopanetsoeng le mesifa e phutholohe narcotic analgesics khoneha ho tepella maikutlo ea setsi sa matšoafo le ntshetsopele ya robala apnea.

Tšebeliso ea lithethefatsi le depolarizing relaxants mesifa mofuta oa bohato ka bobeli ntlafatsa le tsa fokodisa kakaretso mesifa e phutholohe sebediswa. boemo Sena ke ka lebaka la litekanyetso li behoa ea lithethefatsi, nakong ea tsamaiso, 'me ba nahanela motho ho moriana.

bofello

Jereng mesifa boikhathollo nakong opereishene - karolo ea bohlokoa ea e thethebatso lotaganngwa. Lithethefatsi "pipekuroniyu lethal gene" e ka katleho a sebelisa ho ikwetlisetse tsa bongaka merero tsena.

E lokela ho a hopola hore ho qaloa ho moriana etsa hore ha feela boikhathollo tsa mesifa ya marapo le boikarabelo ba ho mokhatlo oa boithaopo, empa hape o etsa hore shoele litho tsa mesifa matšoafo. Ho nahana ka sena, lithethefatsi e sebediswa feela tlas'a maemo a le ho buoa matla diyuniti tlhokomelo.