"Mesipol": litaelo bakeng sa ho sebelisoa, counterparts ea sebele

ke lithethefatsi "Mesipol" ke efe? ka kopo ya sesebelisoa motataisi, lona contra-ho bonahala 'me li tla tšohloa sehloohong sena. Hape, u tla ithuta hore na kapa ha meriana ena le liphello tse neng li tla ba ka ketsahalo ea overdose e, mofuta o eo e marketed le seo ntho e na le.

Foromo ya lithethefatsi le ho hlophisoa lona

Ho lokisetsa "Mesipol" e marketed ka mefuta e 'meli e fapaneng: matlapa le tharollo bakeng sa ente intramuscular. bueloang bona molao-motheo e tšoanang. Haeba ke ke ha khoneha tsamaiso molomo, ente e sebediswa.

The tharollo "Mesipol" e na le karolo ea motho ea mafolofolo kang meloxicam. Ho boetse ho akarelletsa tse latelang metsoako ea thusang: glycofurol, meglumine, sodium chloride, Poloxamer 188, hydroxide sodium, glycine, le metsi bakeng sa ente.

The tharollo e na le 'mala o mosehla kapa bosehla bo botala-. Ho e bonaletsang. Hape e na le monko o bath. The lebokose ena e 3 ampoules (1.5 di ml).

Tshohanyetso, ho phaella ho matlapa kapa ditharollo tsa liente intramuscular, lik'hamphani meriana o ile a qala ho hlahisa likerese "Mesipol" le suspensions ne a rerile hore tsamaiso molomo.

Litšobotsi diokobatsi ya moriana

"Mesipol" lithethefatsi ke nonsteroidal-ba khahlanong le a hlabang moemeli. Lithethefatsi ha e khone ho ikitlaetsa analgesic le antipyretic sebediswa. Phello antiinflammatory ea mokhoa oa ho kopanela le slowing tsa mosebetsi enzymatic tsa cyclooxygenase-2, e leng ho akarelletsa ho biosynthesis tsa prostaglandins sebakeng ruruhileng.

Ho e monyenyane a sebetsang a meloxicam elements sebetsang sebakeng sa hae ka cyclooxygenase-1, e leng e ameha ka ho toba ka prostaglandin tswakana, eo ho sireletsa lera mucous ea intestine le sebetsang sebakeng sa hae ka molao oa tsamaiso ea phallo ea mali ka ho a liphio le.

Pharmacokinetics ya moriana

Lithethefatsi "Mesipol" (liente le matlapa) e ananelang ka ho feletseng. The bioavailability ea lithethefatsi ke 100%. Mora ente intramuscular (ka bang 15 mg, meloxicam), ho absorption lebetsoeng le e fihlellwa ka mor'a metsotso e 65.

re nahana ka lithethefatsi tlama ho liprotheine lero la mali, ho akarelletsa le albumin (99%). Ho habonolo feta mekoallo ea mali-dinama tse nyenyane tse, empa hape le kenella ka hare ka mokelikeli mokelikeling. mahloriso le ho eona ke 50% ea mahloriso ea lithethefatsi ka lero la mali.

Ntho mafolofolo moriana o e hoo e ka bang ka ho feletseng metabolized ka sebete. Ena e bopa e mene diokobatsi khathetseng moeeng metabolite.

Ka mor'a ho sebelisa moriana o ka ka tsela e tsoanang a bonahatsa intestine le a liphio (a metabolite). Ka karolelano halofo bophelo ba boleng bo le mafolo-folo ke lihora tse 20.

Bontšang bakeng sa tshebediso ya meriana

Maemong a mang, ho laela "Mesipol"? Litaelo tsa Sebelisa e bolela hore hangata ka ho fetisisa ho kgothaletsa ho sebelisa NSAIDs ea ho phekola bontshang matshwao ya mafu a tse kang:

• tabanan;
• ramatiki;
• Ankylosing spondylitis (kapa ankylosing spondylitis).

Ho phaella moo, lithethefatsi "Mesipol" (liente le matlapa) e atisa ho ba laela hore ba bang le holofatsang le a hlabang mafu a manonyeletso, tse tsamaeang le utloe bohloko bo boholo.

Contraindications ho tshebediso ya mahlahana a batho bao e seng steroidal

Maemong a mang, meriana ke ke sebelisoa "Mesipol"? Litaelo bakeng sa ho sebelisoa e na le lethathamo le leholo la contraindications. Tsena li akarelletsa tse latelang:

• Hypersensitivity ho elements mesebetsi e amanang le lithethefatsi, kapa metsoako e thusang;
• leeme kapa ka ho feletseng motsoako oa asma, ho se mamellane ea acid e acetylsalicylic, polyposis (iphetang) paranasal sinus le cavity nasal, le NSAIDs tse ling, ho akarelletsa le anamnesis ea;
• lilemo tsa bana (dilemo 16-18);

• ulcerative kapa diso erosive ea mucous lera 12 tiperstnoj intestine kapa mpeng;
• kanyeso;
• cerebrovascular mali kapa tse ling tse hlahang ho yona tsoa mali;
• a sebetsang a tsoa mali ka e ntse likahare ka kapa mpeng;
• nakong emara (bokhachane);
• hlabang mantle a lefu (mohlala Crohn ya lefu kapa ulcerative colitis);
• tsoelang pele renal lefu, ho akarelletsa le hyperkalemia (tiisa);
• nako mora gogoga mothapo buuoe;
• renal ho hloleha (a bontša) ka batho ba sa kang ba li behiloe tlas'a dialysis (CC ka tlaase ho 30 di ml / mets);
• decompensated pelo hloleha;
• letotong mafolofolo tsa lefu sebete le ho hloleheng sebete (haholo).

Sebelisa hlokolosi feteletseng!

Hona joale hore u tseba ho e mabokosana u ka sebelisa lithethefatsi "Mesipol" (matlapa, liente), 'me seo e contraindicated. Leha ho le joalo, ho na le maemo moo re li tšohlileng lithethefatsi lokela ho tsamaisoa ka hloko feteletseng. Nahana ka lethathamo la Maemong a joalo:

• botsofali (lilemo tse 60);
• gogoga lefu la pelo;
• foleng ha pelo;
• mafu cerebrovascular;
• lefu la tsoekere;
• dyslipidemia kapa hyperlipidemia;
• pheriferale mothapo lefu;
• creatinine rengwa ka tlase ho 60 ML / mets;
• ho tsuba;
• diso ulcerative ea tsamaiso tshilong ya dijo ka histori;
• tšebeliso ea nako e telele ea lithethefatsi bao e seng steroidal, hammoho le ho sebelisa ha bona bo sa laoleheng ka tekanyetso e kholo;
• e tshwaetso, e tsejoang e le Helicobacter pylori;
• kamehla tshebediso ya ea lino tse tahang (esita le dikahare tlaase ea joala);
• a le mong-nakong tshebediso ya corticosteroids molomo, ho akarelletsa le "Prednisolone" lithethefatsi;
• haholo somatic tsela e sa tloaelehang;
• pataganeng tshebediso ya anticoagulants (mohlala, lithethefatsi "Warfarin"), antiplatelet mahlahana a (ka mohlala, acetylsalicylic acid e le lithethefatsi "Clopidogrel"), hammoho le inhibitors (khetha) serotonin reuptake (o kenyelelitseng lithethefatsi "Tsitmedialopram" "Fluoxetine", "Paroxetine" le "sertraline").

Nonsteroidal-ba khahlanong le a hlabang lithethefatsi "Mesipol": litaelo tsa tšebeliso

tsamaiso Intramuscular ya moriana o ka pele ho re bontša feela bakeng sa ea pele matsatsi a 3 ea phekolo. Nakong e tlang, re tsoele pele ho fumana phekolo le ho nyanyana litho tsa mefuta e meng ea meriana, ke hore, matlapa a.

The kgothaletswa litekanyetso li behoa ea le moemeli e 7,5 mg, kapa 15 mg, hang ka letsatsi. A palo e filoeng moriana itšetlehile ka matla a bohloko, hammoho le ho tiea tsa tshebetso a hlabang. moriana o le e laolwa ke tebileng ente intramuscular.

Ke ho ka khoneha ho ba kopanya le tse ling tse lithethefatsi lithethefatsi "Mesipol" (Shots)? Thupelo ea tsa moriana o bolela hore litaba tse ka hare ya vials tabeng leha e le efe a ke ke a tsoakane ka ente e tšoanang ka tharollo tse ling. Sena ke ka ntlha ya go ha e le hantle hore ho na le kgonego phahameng tsa lumellane ho ba motho ea mafolofolo ntho meloxicam le dikarolo tse ding tsa bongaka.

Re lokela ho hlokomela hore ho bakuli ba na le kotsi e eketsehileng a itšoare bohloko, hammoho le a liphio hloleha (a bontša) on hemodialysis, e nonsteroidal lithethefatsi litekanyetso li behoa lokela ho ba phahameng ho feta 7,5 mg, ka ho ya ka letsatsi.

Ho boetse hoa hlokahala hore re hopole hore lithethefatsi "Mesipol", analogues ya eo re neng re tla ela hloko ka ho eketsehileng, haeba leha e le efe ha aa lokela ho tsamaisoa entoe.

The lebetsoeng le letsatsi lethal dose ea meloxicam elements le mafolo-folo e lokela ho ba 15 mg,. Ka tsela e lekanang tsa moriana o lokela ho lateloa le ho sebelisa a ikopantseng a matlapa a, suspensions, bakeng sa tsamaiso molomo, suppositories, 'me a entoe nameng.

maemo a ho overdose

Na ho na le maemo a ho overdose ho tswa ho tshebediso ya "Mesipol" lithethefatsi? Liente (ulasan pelanggan e mabapi le bona e tla tšohloa qetellong ea sehlooho se reng,), lipilisi, suppositories le suspensions ka etsa hore ba futsanehileng e motho ha sebelisoa laolehang le ka meqolo e kgolo.

Matšoao a overdose ka 'na a akarelletsa maemo a latelang: ho nyekeloa ke pelo, nang le bokooa ka ilibana, bohloko epigastric, a hlobaetsang le ho hloleha renal, ho hlatsa, ho tsoa mali ka mpeng kapa mala, ho hloleha sebete, asystole, le ho hema ho tšoaroa.

Seo a ka se etsa ka tabeng ea overdose e? Litsebi nkhothaletsa gastric lavage, hammoho le sa phekolo bontshang matshwao.

Ke tsela eo, ka tsela ea lithuto tsa tleleniki li bontšitse hore cholestyramine thusa potlakisa ho felisoa ha meloxicam. Hemodialysis overdose ke thuso, kaha ho na le le kamano e phahameng ho liprotheine mali.

litla-morao

E ka etsa hore liphello tse lithethefatsi "Mesipol" (Shots)? tabeng ea ho sebelisa mahlahana a batho bao e seng steroidal Guide e bolela hore e ka etsa hore palo e khōlō ea liphello tse mpe. A re ke re tšohleng lipotso tseo ka ho qaqileng le ho feta:

• Tshilong ya dijo pampitšana: dyspepsia, letšollo, ho nyekoa ke pelo, perforation pampitšaneng ena tshilong ya dijo, bohloko mpeng, ho hlatsa, flatulence, pipitlelano, e fetang eketseha transaminases (sebete), burp, hyperbilirubinemia, ulcerative kapa erosive diso ea tsamaiso tshilong ya dijo, esophagitis, stomatitis, keneletseng kapa patiloe mali ho tswa ho tshilong ya dijo pampitšana, colitis, gastritis le lefu la sebete.
• Letlalo: lekhopho, pruritus, bullous lekhopho, letlalo lekhopho, photosensitivity, Stevens-Johnson lefu, etymology multiforme, epidermal necrolysis nang le chefo e.
• tsamaiso e khopo hemopoietic: khaello ea mali, thrombocytopenia, liphetoho bokelletse mali le leukopenia.
• Allergy: angioedema , le anaphylaxis.
• Tšohile System: molikoalikoane, ho tsekela, pherekano, hlooho e opang, lability maikutlong, tinnitus, disorientation 'me ho otsela.
• tsamaiso e khopo matšoafo: bronchospasm.
• tsamaiso e khopo la pelo: a tatela mali ho letlalo, edema pheriferale, palpitations le khatello e phahameng ea mali.
• Litho tsa ka hare ea pono: lerootho kapa litsebeng pono, conjunctivitis.
• tsamaiso e khopo mosese: hlobaetsang hloleha renal, hypercreatininemia kapa ho eketseha ha urea mali, interstitial nephritis, hematuria le albuminuria.
• liphetoho Local: bohloko le tukang ka sebaka sa ente intramuscular.

Sebelisana le lithethefatsi tse ling

• Ha e mong oa nako e tšebeliso ea lithethefatsi tse ling tse nonsteroidal le asiti acetylsalicylic ho eketsa kotsi ea seso le diso erosive pampitšaneng ena tshilong ya dijo, ekasitana le ho tsoa mali ka bona.
• Le ho sebelisa tsoa hong ea lithethefatsi le antihypertensives ke ho ka etsahala ho fokotsa ho atleha ha e qetellang.
• Tsoa hong kalafo meriana "Mesipol" le phekolo lithium khothalletsa bokella ea bobeli le eketsa liphello tsa eona tse nang le chefo.
• Ha e mong oa nako e sebelisa "methotrexate" le bolela ho eketsa liphello tsa eona lehlakoreng tsamaisong ea hematopoietic.
• Tsoa hong tshebediso ya lithethefatsi "Mesipol" le diuretics ena e kotsi ea renal ho hloleha.
• E mong oa nako e sebelisoa le cyclosporine eketsa liphello nephrotoxic ea chesehang ea mafolofolo ntho meloxicam.
• Le tsoa hong sebelisoa le intrauterine lithibela-pelehi fokotseha ho atleha ha e qetellang.
• Ha e mong oa nako e tshebediso ya e anticoagulant le mahlahana thrombolytic ho eketsa kotsi ea mali.
• Tsoa hong tshebediso ya bao e seng steroidal lithethefatsi "Mesipol" le kolestiraminom kgothaletsa excretion lona ka tsela litho tsa gastrointestinal. Hlahellang ka lebaka la ho kopanya ea meloxicam.
• Lahloang le meriana le inhibitors ya (khetha) serotonin reuptake haholo ho eketsa kotsi ea ho tsoa mali ho tswa ho pampitšana gastrointestinal.
• lithethefatsi Myelotoxic eketsa poleloana gematotoksichnosti a sebetsang a ntho meloxicam.

tataiso e itseng tabeng ea ho sebelisa lithethefatsi

• Lithethefatsi "Mesipol" lokela ho ba le hlokolosi ho feteletseng ka bakuli ba peptic seso a mala le mala, hammoho le batho ba ka anticoagulant phekolo.
• Nakong ea kalafo ka meriana ena ho hlokahala hore ho ho laola ba ditekanyetso tsa mosebetsi renal, haholo-holo batho ba holileng le bakuli ka ho hloleha foleng pelo.
• Bakuli ba ka nako fumana diuretics le bolela "Mesipol", ba lokela ho noa metsi a mangata.
• Haeba ka tsela ea phekolo, mokuli a hlaha kulisoa, le lethal dose ea meriana e lokela ho khaotsa.

Analogues le theko ea lithethefatsi

Ke bokae e rona nkoa e le ea lithethefatsi? The famasi injectable mofuta o mong oa lithethefatsi e ka rekoa bakeng 400 Russia li-ruble. Ha e le matlapa a, suspensions le suppositories, theko ea bona e ka tlaasana.

Ho thoe'ng haeba u ne a ke ke reka lithethefatsi "Mesipol"? Analogs ha matlotlo a rekiswang hoo e batlang e tsohle drugstores. Har'a bona ke lithethefatsi tse latelang: "Amelotex", "Eksen-Sanovel", "Artrozan", "Matar", "M-Cam," "liberum", "Medsikam", "Melbek", "Melox", "Bi- Xico "," Meloxicam "," Melox "," Meloflam "," Miksol-Aude "," Mirloks "," Movalis "," Movasin "," Moviks "," Lem "," Oksikamoks "joalo-joalo.

"Mesipol": ulasan pelanggan ya moriana o

Hona joale u tseba hore ke lithethefatsi re hlahloba. Ho nako ea ho fumana hore na bakuli ba a re'ng ka "Mesipol" lokisetsa. Reviews ena nonsteroidal-ba khahlanong le a hlabang ho bolela hlakang. Ka lehlakoreng le leng, bakuli ba ba bolela hore ho molemo lopollang syndromes bohloko tse sa tlholeho ka tabanan, ramatiki, ankylosing spondylitis le maloetse a mang le holofatsang le hlabang la manonyeletso. Ka lehlakoreng le leng, bakuli ba hangata e tletleba ka hore lithethefatsi e etsa hore palo e ka toka khōlō ea litla-morao, ka lebaka la seo ba neng ba ba qobella hore ba khaotse ho ho nka e.

Ka kakaretso, lithethefatsi pele ho re "Mesipol" ka ho feletseng tsoeroe ke lefu la ka mosebetsi oa eona.