Lithethefatsi "Aspekard": litaelo bakeng sa ho sebelisoa, analogs, ulasan pelanggan

asiti Acetylsalicylic (Asa) e bua ka lithethefatsi le litla antipyretic,-ba khahlanong le a hlabang le antiplatelet. Ikatisetsa tsa bongaka e sebelisoang ka lilemo tse fetang 125, hobane ke e mong oa lithethefatsi e ngata a ithuta. Moo Asa ke hona joale e fumanehang ka kardioformy ho fokotsa menyetla ea thrombosis gogoga mothapo, e sitisa tsoelo-pele ea infarction myocardial. A mohlala tloaelehileng ke oa ho lokisetsa "Aspekard" eo e na le acetylsalicylic acid e ka homolog lethal dose bakeng sa e le hantle antiplatelet.

Tlhahisoleseding e mabapi le ho lokolloa ha mofuta o le Manufacturer

The moetsi oa moriana ke Seukraine khampani "Stirolbiopharm". Ka lebaka leo, theknoloji difeme sebelisoa, ya hlahiswa ka liforomo foromo zheludochnorastvorimoy ka lethal dose ea la mg, 100 ka Letlapa. Mekhoa Tablets moralo:

• lebokose matlapa 120 (10 ho 12 machachetsi tab ya.);
• setshelo polymeric matlapa 100.

Letlapa "Aspekard" e na 100 mg, ea Asa, microcrystalline selulose, croscarmellose sodium, colloidal silicon e dioxide, acid e stearic.

Likhothaletso hore a khethoe

Ka ho lokisetsa "Aspekard" kopo e moqotetsane lekana, le hoja ho na le litaelo tse ho likhothaletso bakeng sa kalafo ya mafu a mangata, ho akarelletsa le mafu rheumatic. Manufacturer kgothaletswa "Aspekard" hape e le moemeli antipyretic kapa analgesic. Ha e le hantle, ka litekanyetso li behoa ea phekolo acetylsalicylic acid e ka feela tle o sebelisoa e le lithethefatsi tseo thibela platelet aggregation.

Ho bonahala "Aspekard"

Ka ho lokisetsa "Aspekard" taeo ka kopo ya, lekodisisa profesionalce ho etsa lipatlisiso tsa tleleniki le fa e ngata lesedi amanang le antiplatelet phekolo. E o ile a bontša maemong a latelang:

• ha (ACS), a hlobaetsang le gogoga lefu (ka mohato hlobaetsang bophahamo myocardial infarction, ho tepella maikutlo kapa senyeha ST karolo sebaka, ka tsitsang angina);
• le leqeba (ischemic setorouku kapa e fetang ischemic tlhaselo);
• tabeng ea proven lefu gogoga mothapo e le mokhoa oa ho thibela gogoga syndrome, a hlobaetsang le leqeba;
• ka thibelo ea mananeo e iphetang ea gogoga syndrome, a hlobaetsang le leqeba;
• le ho ba teng ha methapong varicose;
• e le moemeli e thibelang, e be temoso shunt thrombosis mora CABG;
• le kgatelelo ya madi ke le nehile e phahameng kotsi pelo le methapo.

Phahameng la pelo kotsi ke kgopolo ya go aggregate e akarelletsang ho ba teng ha setho sa tšenyo e korotse ka kgatelelo ya madi le mafu a amanang le: lefu la tsoekere mellitus, gogoga mothapo lefu, TSVB.

Features litekanyetso li behoa regimens kgothaletswa ke moetsi

Ka ho lokisetsa "Aspekard" mohlahisi amohele taeo hase boeta-pele e khōlō ea kalafo oa mokuli. E na le boitsebiso bo mabapi le tsamaiso ea lithethefatsi maemong a fapaneng litleleniki tsa ho tloha ho thibela liketsahalo atherothrombotic ka CHD le TSVB le ho ipolaea le maloetse a hlobaetsang le tsa ajoa ka likopi 'me pelo ea bokong. ho se phethise ketso ena e nkoa e hlokomoloha le unprofessional boikutlo bo ho taba ea ho sebelisa lithethefatsi le ho tsamaea le thepa e bona boitsebiso. E boetse e baka e preconditions ho phatlalatsoa boima la lihlooho eo dosages kgothaletswa fapana.

Dosing regimens motheong oa likhothaletso machaba

Motheong oa melao e tataisang ea machaba ntshetswa pele ke Community Europe la Cardiology (esc lena) le American Heart Association (Eke) le ikamahanya le maemo ka ho Lekala la Bophelo, le mekhoa ea ho sebelisa acid e acetylsalicylic ke tse latelang:

• ka mohato tshohanyetso nakong syndrome, a hlobaetsang le gogoga Ho hlokahala hore a fane ka mamello ho hlafuna matlapa 3 "Aspekard 100". Litaelo bakeng sa ho sebelisoa e hlokomoloha, le lethal dose ea se nang molekane ea 300 mg,;
• foleng cardiac ischemia (CHD) moketeng oa lenyalo kamehla abeloa mong letlapeng la 100 mg, ka shoalane ka mor'a lijo tsa mantsiboea;
• le kgatelelo ya madi bakuli ba le kotsing e khōlō ea la mathata a pelo le methapo, hammoho le venous varicose kamehla e amohetsweng ka ho 100 mg, (1 Letlapa) mantsiboea ka mor'a lijo tsa mantsiboea.

litsela tse ling tsa tsamaiso ea lithethefatsi "Aspekard" taeo esc lena le Eke ha fana ka. Ho boetse ke habohlokoa ho ela hloko hore tekanyetso lethal dose "Aspekard" ke 100 mg, ea Asa. Bakeng sa thibelo ea mafu a ka holimo, ho latela litaelo esc lena le Eke, sebediswa lethal dose ea 75 mg,. Leha ho le joalo, 100 mg, ka abeloa bakuli mora CABG ho thibela thrombosis tsa shunt ena. Maemong a mang e kgothaletswa ho etsa kopo ya 75 mg,, i.e. chelete sa Asa, e leng e fana ka a lekaneng antiplatelet sebetsa mme o na le bonyane kotsi gastrotoxicity.

Hape, moetsi ha fana ka litaba tsa bohlokoa ka bo felisoe ya moriana. Ho ea ka lipalo-palo, e cessation tšohanyetso la nyeoe ea 10.2 batho% ya liketsahalo hlobaetsang pelo le methapo. 'Me ba fumana ka mor'a hoo e ka bang 10,6 matsatsi a ho tloha letsatsing leo hlakoloa ha Asa. nako ena ke karolelano le bontša nako ea eo ho eona baahi bohle e fokotsehile platelet cyclooxygenase tshebetsong. Ka lebaka leo, ka monyetla oa ho clots mali tsosolosoa. Hobane lithethefatsi lokela ho ho nkoa ka tswelela pele, ha ho khethoa moemeli e mong antiplatelet ho ena le "Aspekard" ponahalo ea mathata pampitšaneng gastrointestinal hlokahala.

Contraindications "Aspekard" ho lokisetsa

Tšireletseho ea lihlahisoa tsohle meriana ke mong ka bona, hobane ba na le litla-morao. Ka nako e tšoanang ba etsa hore ba bang ba contraindications. Ka ho khetheha:

• ka mafu a ea coagulation mali (hemorrhagic diathesis, hemophilia A le B);
• ka mafu a ea likarolo mala (erosions, liso tsa ka maleng a hlobaetsang ea mala le duodenum 12);
• nakong ea trimester pele a bokhachane le diabolololo;
• ka matla kholofalo renal kapa e amanang le sebete;
• ha kulisa ho salicylates;
• bana ba ka tlaase ho feta lilemo tse 18;
• ka ho ba teng ha asma bronchial;
• ea ho phekola ba methotrexate.

contraindications tsena ke ka ho feletseng, le hoja ba bang ba nako: diabolololo, bokhachane, khoholeho ea mobu le liso tsa pampitšana gastrointestinal, boseeng. Le hape ho na le ke sehlopha ea bolela, ho ba teng ha ho ea eona e hloka go baya leitlho ea kamehla ke ngaka. Sena tšebeliso tsoa hong ea antiplatelet phekolo le anticoagulants, le kalafo ea bakuli mora gogoga opereishene mothapo kgaoleditse. Ha mosebetsi a liphio sebelisoa ho lithethefatsi "Aspekard" litaelo bakeng sa ho sebelisoa hloka phokotso litekanyetso li behoa kapa tlatsa messengers butle-butle moriana.

litla kopanetsoeng "Aspekard"

asiti Acetylsalicylic o sebelisa litla hore ntlafatsa kapa depress ketso ya lithethefatsi tse 'maloa. Ka ho khetheha:

• Asa kgothaletsa phello ea anticoagulants efe kapa efe le mahlahana antiplatelet;
• Asa kgothaletsa antipyretic le analgesic phello ea NSAIDs, amplifies antirheumatic e le hantle "Meloxicam";
• ha ho kopantswe le lithethefatsi cytotoxic kgothaletsa gastrotoxicity bona;
• ha ke tlosoa le joala kotsi la mathata seso kapa eketseha mali;
• glucocorticoids keketseho e gastrotoxicity "Aspekard";
• ACK attenuates le phello diuretic ha ho kopantswe le diuretics "Furosemide", "torasemide", "spironolactone".
• "Aspekard" fokolisa phello ea mahlahana uricosuric, "Probenecid", "Etamid", "sulfinpirazon";
• nonabsorbable antacids fokotsa ho absorption ea "Aspekard".

Kgonego ya e overdose le matšoao a lona

Batlang e le lithethefatsi "Aspekard" taeo, ditshwaelo le ho sebelisoa ha lipalo-palo netefatsa phahameng boemo ba lekane ka tshireletso moketeng oa lenyalo ho ea ka ho bonahala le contraindications mokhelo. Sena se bolela hore lethal dose e balletsweng ya 100 mg, ea lithethefatsi ke sireletsehileng ka ho lekaneng, le hoja taolo ea puso ea bophelo bo botle ke ho hlokahala. Ho feta moo, ka lebaka la ho cohort ea bakuli le ho batla ho ipolaea, hammoho le kotsi eo matlapa a Asa tla nka ngoana, dintlha hlokahala kgonego overdose le matšoao a eona.

Maikutlo a chefo salicylates, halefisoa ke kopo ya ba lokisetsa ho "Aspekard" ntle le matšoao a ngaka dikgothaletso ke re ho latelang: ho tsekela, bohloko ka fossa podlozhechkovoy, sebaka lelana, ka linako tse ling bohloko, haholo-holo ka bakuli ba lefu a liphio. Tabeng ea overdose ka ho na le e qhaqhasela, ho hlatsa ka linako tse ling le streaks tšollang mali. Ea pele ke ka tsela e induction maiketsetso tsa emesis: ea tletseng batang seno, butswe mokhoa mashala le ehnterosorbentov pelehi le mamello ka sepetlele.

Sa bohlokwa hape, ho tekanyetso chefo "Aspekard" taeo pukwanana ha bolela ka ho toba. Ba fapaneng bakeng sa boima ba 'mele e fapaneng le lilemo tsa ba le mamello. Ka mohlala, ka motho e moholo batho overdose matšoao a bonolo Asa etsahala kenoa le 'ngoe ka 5-7 dikgerama acid e. Bana ba ba le ka ho lekaneng hore e overdose ea 1.5 g, lethal dose 'ngoe. A overdose khōlō ho etsahala ha ho sebelisa dikgerama 7-9 ya batho ba baholo le bana ba 2-2.5 a mob mobile ea Asa.

lengolo la ena ea overdose ea lithethefatsi o ile a bontša ka ho mafu a tse ka holimo tse amang mesebetsi dikopanothutano. Lahlehileng ha noutu qala tinnitus ho nahana e ba ferekane, puo incoherent. Ho hlatsa, hangata e etsahalang, ho ba le mamello ka potlako ea lahleheloang mokelikeli ho tswa ho hlatsa, ho hema quickens, ho na le a hlobaetsang le mosese tshegetsa le go tlotla, e ile ea eketseha mocheso oa 'mele. Thusa mokuli a le boemong bo joalo ke ke ha khoneha ho nosi - pelehi hlokahala ka NICU bakeng Infusion phekolo bicarbonate, sodium lactate.

Features ya bohato phekolo "Aspekard"

Khomaretse moriana "Aspekard" sebetsa taeo e kenyelletsa ditokiseletso sesupo sa baeti ba fihlelang ho ea letlapa e mong ka letsatsi (100 mg, / ka letsatsi a). lethal dose ena Asa ke lekane ho thibela metsoako platelet cyclooxygenase. Phello ke thibelo ea tswakana tsa thromboxane A2, eo ka ho feletseng thibela bokhoni ea lisele ho platelet aggregation. Sena se felisa ka monyetla oa ho thrombosis, e leng sesosa sa myocardial kapa bokong infarct.

Ho fana ka le phello antithrombotic ea acid e acetylsalicylic lokela ho kena maling. Leha ho le joalo, ba bang ba e sebetsang sebakeng sa hae ka mpeng 'me hape ba inhibiting cyclooxygenase-1 le isoforms lona ka mucosa ba lekala la. The lebaka la mochine ona ke ditlamorao - fokotswa bokhoni ba muco-sireletsang mokoallo carbonate. Sena se eketsa kotsi ea erosions le liso tsa mala, di hlohleletsago gastrointestinal-mali. formulations Enteric Hape ba khona ho susumelletsa mali, empa maqhubu tsa ama ena lehlakoreng, ba na le lintho tse nyenyane ka ho fetisisa.

Boimana le diabolololo

Setsebi maikutlo a, e thehiloeng sekasekale dipalopalo le letoto la liteko, e le hore u be le kutloisiso e hlakileng ea ho sebelisa "Aspekard" moriana nakong ea bokhachane. Ka ho khetheha, 1 trimester e sebelisa e thibetsoe. Ho 2 le 3 trimester kopo lumelloa, empa ka mor'a hlahlobo ya e sebelisa phekolo le bapisa le baeti ba fihlelang ho ipeha kotsing. Ka boholo ba litleleniki tsa maemo ho khethoa ha Asa ho sa hlokahale, le hoja NSAIDs tse ling hape ke khona ho eketsa kotsi ea ho senyeheloa.

Nakong ea diabolololo, sebelisa lithethefatsi "Aspekard" analogues eena, generics, hammoho le meriana eohle ka acid e acetylsalicylic ka ea ho hlophisoa e thibetsoe. Lebaka la sena ke ho otla lithethefatsi lebese letsoele. ho kenella ka hare ho esita le eena 'meleng lesea. Le kotsi lona ke kotsing e khōlō ea ho tšoaroa ke lefu Reye ya - e haholo ka ho fetisisa e amanang le sebete magazine, e bakang boko ho ruruha le lefu la ngoana. Ka mabaka a tšoanang, o hanela ho sebelisoa ha lithethefatsi ho pele ka ba lilemo li 16-18.

Tobileng Reviews profesionalce le bakuli

Bontšang lithethefatsi "Aspekard" mamello poeletsotlaleho maemong a mangata e leeme. Ba sebele le lekanyetswa go ya ka theko ea lithethefatsi, kaha ho ke ke hoo e ka bang ka tlaase-tlaase har'a lithaka tsa. Leha ho le joalo, maikutlo a amanang le kopo e sebetsang ea ka tlaase ho moo e bontsha gore ho hlōleha ho hlahloba tekanyo ea bakuli ba fokotsa menyetla ea thrombosis vascular. Ho latela liphello tse tlalehile ke bakuli, lithethefatsi e tšoauoa ka ho lekaneng sireletsehileng.

Maikutlo a litsebi tse hlakileng: pele tefong, lithethefatsi ke atleha ho fokotsa kotsi ea thrombosis, 'me bobedi ho, bakuli ba khomarela antiplatelet phekolo e phahame ka lebaka la e tlase "Aspekard" theko ea lithethefatsi e. Analogs tsa sehlopha sa baemeli ba antiplatelet ke haholo e phahameng. Malapeng enteric ho lokisetsa "Atsekardol" theko e phahameng ho feta ka ho 50%, le hoja litšenyehelo tsa ho naha e phahameng ka makhetlo a 7-10. Empa e thehiloeng mahlahana a mmalwa litla-morao enteric, hammoho le ba se fumaneng moruo, ke tse lakatsehang ho fana ka ntho ea bohlokoa ho ho "Atsekardolu". Litsenyehelo tsa ho ba kalafo khoeli e tla ba ka bang 20 li-ruble.

Sepheo ho hloka kardiopreparata "Aspekard"

Khomaretse moriana "Aspekard 100" taeo pukwanana bolela hore lithethefatsi e fumaneha ka matlapa a. Ba qhala ka mpeng le le ho hlahisa ea mahloriso phahameng. Ho Fana ka gastrotoksichesky le phello ea moo, lithethefatsi lahleheloang lithethefatsi Safety Other, e leng enteric. gastric mali kotsi ha ho sebelisa ea bobeli e ka tlase e ngata.

Mehlala ea lithethefatsi sireletsehileng ke tse latelang: ". Aspirini Cardio" "Atsekardol", "Polokard", "Cardiomagnyl", Ho feta moo, o ile a re ho bolela hape di na le dipegelo magnesium hydroxide, ba khona ho sireletsa mucosa kotsing ka acid e acetylsalicylic. Leha ho le joalo, lithethefatsi "Aspekard" 'na ha sebelisoa bakeng sa ho thibela thrombus sebopeho, le hoja ka har'a meeli. Leha ho le joalo, bakuli ba na le mucosal khoholeho ea mobu, seso 12 duodenum kapa mpeng, ho akarelletsa le a sa foleng, ho buelloa ho nka enteric kardioformy acid e acetylsalicylic.

Vneotraslevoe kopo kardiopreparata "Aspekard"

Boholo ba ditaelo tse fumanehang bakeng sa ho sebelisoa e leng se bontšang ho ba teng ea antiinflammatory le thepa antipyretic lithethefatsi "Aspekard 100". Ha e le hantle, pheko e tletseng na litla phekolo ke makhetlo a 5 ho ea se nang molekane lethal dose - 500 mg,. The litekanyetso li behoa ea 100 mg, ke feela cardiac, 'me phello ea oona ho ke ke lekane ho ka tsela e atlehang ho fokotsa mocheso ka mafu a tšoaetsanoang.

Kardioforma ho lokisetsa etsoa lethal dose e le ba 100 mg,, ke a loketse bakeng sa bohloko le phomolo feberu feela le lethal dose ea se nang molekane oa matlapa a 5. Ka tsela eo predominance selectivity bakeng cyclooxygenase 1 rerang ho ba teng ha ka plurality a itšoare lehlakoreng. Ka lebaka leo, ka febrifuge "Aspekard" lipilisi, ya e le hantle, ke loketse. Leha ho le joalo, ka nako eo ho na le a 'maloa a' maloa a lithethefatsi sireletsehileng bontša selectivity khōloanyane ea cyclooxygenase 2. Ba boetse ba litla mmalwa lehlakoreng amanang le tlōlo ea keketseho ea epithelium gastrointestinal.

Safety sehlopha sa counterparts "Aspekard" lithethefatsi

A mokhoa tšoanang ile a hlokomela ka ho phekola mafu a rheumatic. Le khomaretse moriana "Aspekard" taeo bakeng sa ho sebelisoa e na le boitsebiso bo mabapi le kalafo bona. Leha ho le joalo, ho lethal dose kgothaletswa ke ea ka taelo ea dikgerama 5-8 ka letsatsi.

palo ena ea acid e acetylsalicylic bontša gastrotoxicity bapiswego matla le ho feta e le hantle ho feta ha "meloxicam" meriana, "celecoxib", "Roferoksib" le ba bang. Le ka antipyretic bohlokoa ka ho fetisisa sehlopha sa manaka ke "Ibuprofen".