Lipid peroxidation (LPO) ke kgokahanyo ea bohlokoa ka phapanyetsano tshilong ya dijo. Mosebetsi motheo ea eona ke ho ntjhafatsa ea lipids tsa lera la seleng.
Ka bophelo bo botle motho lipid peroxidation laoloa ke seo ho thoeng ke antioxidant tsamaiso e o laola lebelo le phosphorylation mosebetsi ke tlama lintlha sisinyang maikutlo kapa kokobetsa ho bongata lekaneng peroxides ho thibela e overabundance tsa lihlahisoa qetellong ea metabolism. Kholiso thulaganyou e ho kena moea e ka 'na ntlha qalang ka pathophysiological dithulaganyo bohlokoa mafu bokae. Tšebetso ena e kenyeletsa mohato oa enzymatic le batho bao e seng enzymatic autoxidation.
mefuta
Ho fetoloa le bilayer phospholipid tsa lera seleng ea fetela le enzymatic ho kena moea. Ho phaella moo, ho akarelletsa le sebōpeho sa dintho biologically mafolofolo, detoxification, liphetoho tshilong ya dijo. Bao e seng enzymatic ho kena moea o bontša ka boeona e ka ntlha e senyang ka bophelo ba ka seleng. Ka lebaka la hore ho thehoe e ngata ea radicals mahala le peroxides bokella antioxidant oona tsamaisong mosebetsi fokotseha le ka lebaka leo, ho na le ho timetsoa ha lisele tse phelang.
PAULUSE potoloho
Ho qala lipid peroxidation hlokahalang teng ha oksijene mahala radicals, ho ba le boemo eneji, le ka ho feteletseng 'ngoe le elektrone unpaired. Ka mor'a ho hlaphoheloa ea limolek'hule oksijene ya hlahiswa superoxide eo a leka ho le liathomo hydrogen, ho retelehela ka peroxide hydrogen. Bakeng sa ho laola tjhelete ya superoxide hare lisele tse teng superoxide dismutase, eaba ba etsa peroxide hydrogen le catalase, peroxidase kokobetsa ho e metsi. Ha e phelang phelang ile a pepesa ho ionizing mahlaseli, palo ea mahala radicals hydroxyl tla eketsa ka tsela e hlollang. Ho feta moo hydroxide oksijene le lona mefuta e meng le mafolo-folo le ka qala tshebetso fono lekgetlo la peroxidation lipid.
Products tsa lipid peroxidation kapa phelang lahloa, kapa sebediswa bakeng sa tswakana tsa prostaglandins (dintho ho akarelletsa liphetoho ho ruruha), thromboxanes (kenyelleditswe thrombogenic phorosela a itšoare), li-hormone adrenal.
tsamaiso e khopo taolo
Ho itšetlehile ka lera seleng ea lebelo sebopeho botlaaseng, 'me palo ya mosebetsi oa lihlahisoa sephetho le ho kena moea e ka fapana. Ka mohlala, mosebetsi oa lipids peroxidation holimo moo e le karolo ea leboteng seleng ea e busitse unsaturated acid tse mafura, 'me butle, haeba motheong oa COP ke k'holeseterole. Ho phaella moo, ntlha e laola chelete le tekanyo ea sebopeho sa mahala radicals oksijene, hammoho le tshebediso ya peroxides, ke tshilong ya dijo ka potlakisang tsebetso ea lik'hemik'hale. Esita le ka itšoara joang ea lipids peroxidation sebetsang dintho tse amang lera seleng ea lipid sebopeho le phetoho hatellang ho latela litlhoko tsa ba phelang. Tsena li akarelletsa vithamine E le K, thyroxine (thyroid li-hormone), hydrocortisone, cortisone le aldosterone (of ditshwaelo tsa). Destabilizing seleng ea leboteng tšepe ions, divithamini C le D.
tlōlo ea tshebetso
lihlahisoa tshilong ya dijo tsa lipid peroxidation ka 'na ipokellela ka lisele le maro a' mele ntle le antioxidant tsamaiso e khopo ha e lahla ba le lebelo ho hlokahala. Ka lebaka leo sitisa ho tsamaisa ya ions mose ho lera seleng, eo tsela e sa tobang a ka susumetsa ea ho hlophisoa ionic tsa karolo mokelikeli oa mali, tekanyo ea karohanyo le depolarization tsa lera mesifa seleng ea (roba conduction la litakatso tsa methapo ea kutlo, contractility bona, prolonging nako refractory), bebofatsa mosebetsi wa ho kena ea mokelikeli sepakapakeng le kantle ho sele (edema, clots mali, electrolyte imbalance). Ho phaella moo, lihlahisoa tsa sehlooho tsa peroxidation lipid, ka mor'a letoto la liphetoho skeletal, ba sokolohela aldehydes, ketones, acid le tse ling tse joalo. Dintho tsena ba le phello e nang le chefo e ka 'mele, e bontša ka boeona e ka sekhahla phokotsong ea DNA tswakana, eketsa capillary e lumellang metsi ho kena, eketsa khatello ea oncotic, joalokaha ka lebaka leo, sludge-lefu.
Liponahatso ka tleliniking
Ho tloha ka ho eketseha ha oksijene mahala radicals na litla kotsi leboteng ka seleng, 'me lihlahisoa tsa metaboliki senya metabolism le tswakana ea acid nucleic le chefo' meleng, ba pathophysiologic Ntlha e ka ho hōla ha palo ea maemo ea tleleniki. Karolo e phethoang ke peroxidation lipid ka sebete ke lefu bohlokoa ba manonyeletso, parasitic maloetse a tšoaetsanoang, mafu hemodynamic, mafu oncological, ke maemo a sithabetsang le ho chesa. Pol ke e 'ngoe ea lintlha tsa atherosclerosis. Free radicals oxidize k'holeseterole le lona tlaase limolek'hule boima karoloana ya ho theha lihlahisoa hore senya lerako vascular. Sena se qala ka phorosela a itšoare pathological tloaelehileng ho rarolla senya. Sena se qholotsa clots mali, bokella clots mali ka lumen likepe tse nyenyane kapa re inehele ho mabota bona. Ka lebaka la mokhatlo oa mali sebakeng sena liehisa, ka e se e ntse e le sejana se lumen. Sena se etsa hore ho bokella ka ho eketsehileng clots mali. Ka ho fetisisa qalile ho hlaseloa ke liphetoho tse joalo ka methapo gogoga, ho aorta, o ile a bontša ka matšoao Tleliniki ya lefu gogoga ba pelo.
mehato e thibelang
Lingaka lokela ho hopola hore boitšoaro ba mekgwa ya tshebetso tekotshupo le phekolo ka ebe o kenya tshebetsong le mochine oa lipid peroxidation. Sena se lokela ho lemosa ba le mamello. Ke susumelletsang motho lintlha kenyeletsa mahlaseli phekolo (kankere), mahlaseli khanya (ka rickets, mafu a hlabang tsa sinuses e, antibacterial kalafo likamore), masimo a khoheli (MRI, CT, phekolo 'meleng) mananeo ka kamoreng hyperbaric (ka poliomyelitis, bophahamong kula).
Thibelo le Therapy
Basebetsi ho sebetsa ka rentgenkabinetom, orderlies le baoki, ditsebi ho ea physiotherapy, hloang, batho ba nang le boima ba 'mele ho feteletseng o lokela ho ja lijo tse nang le antioxidants tsa tlhaho: tlhapi, sonobolomo, kapa oli ea mohloaare e, litlama, mahe, green tea. Ho phaella ho ho fetola lijo, lithethefatsi li ka sebelisoa hore a tlangoe ho lihlopha tse itseng kapa mahala radicals kopana le lirafshoa tsa polygonal valency. Kahoo ba ema e sa lefelloeng ea limolek'hule a sebetsang a oksijene, ho thibela ba ho tswa ho tlama ho amplifiers lipid peroxidation.
tlhathoba
Ka ho ba sethaleng jwale ya ntshetsopele ya ho etsa lipatlisiso le laboratori eo re khona ho lemoha peroxide ka ho hlophisoa ha maro a likokoana-hloko tsa 'mele oa motho. Ho etsa sena, phetha khanyang microscopy. Ka mantsoe a mang, ho tsebahatsa lipid peroxidation. Boleng ba teko ena tekotshupo hloka se tlhaloso. Ha e le hantle, ka lefu la bohlokoa chelete e thehiloeng ke mosebetsi ka tsela e feteletseng ea peroxidation lipid. Phumano a puso ena rerang kalafo.
Ho tswa ho le pono e nepahetseng tsa physiology tloaelehileng ea peroxidation lipid hlokahala bakeng sa sebopeho sa li-hormone steroid, mediators a hlabang, ea tse ling le thromboxanes. Empa ha palo ea lik'hemik'hale ya data phapanyetsano lihlahisoa leta lumelleha boleng le ho senya peroxide seleng ea organelles, DNA le senya tswakana ea lihaha-'mele, ha e le hantle o kena antioxidant tsamaiso eo ho fokotsa palo ea radicals mahala oksijene le ions tsa tšepe le polygonal valency. Ho phaella moo, eketsa tswakana tsa catalase le peroxidase bakeng sa lahla peroxides feteletseng le lihlahisoa tsa metabolism bona ka ho eketsehileng.