Bone metastases.

E mong oa mathata a ka sehloohong a ke kankere eohle - ea ke keng ea qojoa qala ho ea ho ba sethaleng ho qetela - ho ba sethaleng sa metastasis. Metastasis foci e bolaeang neoplasms hore le phallo ea lisele tsa mmele kapa mali a tlalehiloe ka makala hōle le lisele tse, moo o qala ho ntshetsa pele thulaganyou e neoplastic.

Kankere ea hoo e ka bang litho tsa ka hare 'ohle le lisele tse ka' na metastasize ho masapo. diso joalo ka fumanoa hoo e batlang e leha e le efe dibopeho masapo. The hangata ho fetisisa - metastases ka lesapo la mokokotlo le, bonyane e noka, likhopo le maoto le matsoho.

Seo lihlahala metastasize ho lesapo la?

Hangata ka ho fetisisa, tshebetso ena e hlaha ha ho thyroid bakeng sa kankere tšoelesa, ea tšoelesa ea senya le ho mammary litsoelesa.

Ho na le mefuta e 'meli tsa motheo tsa thulaganyou e pathological ka lesapo - osteoblastic le osteolytic metatstazirovanie. Bakeng sa lekhetlo la pele mofuta o tiiso ke tloaelehileng ya dinama tse nyenyane tse lesapo, ka ho khetheha karolo ea eona matsoai. Foromo ea bobeli thusa "ho hlatsoa tsoa" oa liminerale, eo hona joang kapa joang se akarelletsa thinning le fractures.

The pathogenesis lefu lena ke hore tse di hlohleletsago lisele tse hlahala. Ha metastasis kankere akarelletsa osteoblasts mosebetsing oa ho - ho ntshetsa pele osteoblastic foromo. Ha hlahala pele e tseleng ea bona kopana lesapo resorbing lisele tse (osteoclasts) - e sebopeho sa metastases osteolysis.

Maemong a mangata, ho hlaha ha metastases ka lesapo le ho ba utloisa bohloko ho qetela. lefu bohloko ho bakoa ke ho senya dipheletso methapo ea kutlo hlahala sekame, keketseho khatello e ka hare ho pele lesapong, 'me ka lebaka la ho teneha dipheletso tsa likhoele methapo ea kutlo abelwa metastasis dintho. Ho phaella moo, bohloko ho etsahala ha lesapo fractures bakoang ke thinning ea ho qetela (bath ea mefuta osteolytic). Ho theha osteoblastic bath bontša hypercalcemia (e phahameng ea mali k'halsiamo).

Kotsi ea fractures ke phahameng kgonego ya mathata a - embolism methapo, tebileng mothapo thromboembolism (qetellong, sena isang felloa ke mosebetsi play loading lekala kapa leoto le solofetsa).

metastases Bone li fumanoa sebelisa X-ray. Bakeng sa morero ona, sebelisa radiography thota ka multiplicity ya diso metastatic, hammoho le foromo osteolytic. Tabeng ea osteoblastic etsoa skena radionuclide. E 'ngoe ea mekhoa ea boitsebahatso, eo ho eona e ka bonoa e seng feela metastases lesapo, empa hape le ka makala a mang le lisele - PET 18P-deoxyglucose.

Ho buoa kalafo ya metastases lesapo ho bontšoa ka khoneha fracture qetela. Ngaka ea Masapo e phethile ho buuoa ho matlafatsa lesapo ka ho kenyeletsa Pinów le tlale hlokisa le lesapo samente hlahala.

Mahlaseli phekolo ka lethal dose e le ba ka bang leshome le metso e mehlano - mashome a mabeli a metso e mehlano ie (attributable ho dikotwana tse 'nè), halofo ea bakuli ke nyamele utloa bohloko. The lethal dose ea mashome a mararo - mashome a mane a metso e mehlano ie o baka Ntlafatso bohlokoa ka boemo ba mokuli, ka ho khetheha lintlafatso joalo ntshetswa pele ka lebaka la ho pepesehela latelang bakeng sa tse peli tse - libeke tse tharo.

Tshebetso bobeli ka mor'a phekolo mahlaseli, ke ho sebelisoa ha strontium ntšang mahlaseli a kotsi. E hona joale ho pharaletseng a sebelisa kalafo bisphosphonate. Sena acid e khethehileng hore thibela metsoako mosebetsi oa osteoclasts. Ho phaella moo, lithethefatsi tsena li ka fokolisa ho tiea la bohloko fractures la masapo a, hammoho le ke tsoelo-pele ea dihlahala.

Kahoo, itse'ng ho metastasis ho lesapo e ka ba e fapaneng, ho itšetlehile ka diriswa tsa osteblastnoy kapa osteolytic diforomo le mekhoa ea phekolo.