Alkaline phosphatase - e lesupa potlakisang tsebetso ea lik'hemik'hale

Ka liketso, baoki ba atisa ho re talimane le keketseho ea tšohanyetso ka mosebetsi alkaline phosphatase. Ka ho sebelisoa ha lebokosana selotlolo teko bakeng sa lithuto tsa skeletal o na le monyetla oa ho ho laola mosebetsi oa potlakisang tsebetso ea lik'hemik'hale le. Ho ea ka boemo ba mosebetsi oa itse potlakisang tsebetso ea lik'hemik'hale le ka khona ho utloa mafu ea tsamaiso hepatobiliary le dinama tse nyenyane tse masapo.

Alkaline phosphatase - e potlakisang tsebetso ea lik'hemik'hale hore ke oa sehlopha sa hydrolases, khomarela sehlopha phosphate tloha biopolymers fapaneng (lihaha-'mele, acid nucleic, alkaloids). Phahameng ka ho fetisisa mosebetsi potlakisang tsebetso ea lik'hemik'hale e ile a hlokomela tikolohong e alkaline. The potlakisang tsebetso ea lik'hemik'hale e teng ka lisele tse amanang le lero la mali lera la mmuso, ka hona ho bua ka potlakisang tsebetso ea lik'hemik'hale lera-tlama. Alkaline phosphatase (ALP) e entsoe ka isozymes fapaneng hore ba kenngoa ka epithelium zhelchnovyvodnyh ducts lera la plasmatic tsa hepatocytes le methapo ea kutlo, lesapo, intestine, placenta, liphio.

Lekanya Ketsahalo ea isoenzymes ke sebelisa electrophoresis. Leha ho le joalo, ALP isozymes ha ba na ka ho hlaka karolo e khethehileng, 'me mekhoa e electrophoretic ke ho le thata haholo. Ka hona, le ho nolofatsa ho etsa lipatlisiso ho sebelisa mokhoa o e thehiloeng isoenzymes fapaneng nahanela ho mocheso. Mala alkaline phosphatase amana karoloana thermostable le isozymes sebeteng le masapo - e thermolabile. nahanela ho fetisisa ho futhumatsa ke lesapo phosphatase.

Serum alkaline phosphatase ke motsoako oa lesapo le sebete isoenzymes. Ho lokolloa ha potlakisang tsebetso ea lik'hemik'hale ho tswa ho mali ka lisele tse fapaneng ho itšetlehile ka boemo ba fisioloji le lilemo tsa phelang (bokhachane, parturition, diabolololo matla). Mosebetsi phahameng tsa phosphatase alkaline maling a batho ba bacha ke e loketseng ho tshebetso e matla ea osteoblasts ka dinama tse nyenyane tse lesapo, tse bakoang ke le thulaganyo ya kgolo mesebetsi e amanang le phelang. Nakong ena, mosebetsi oa potlakisang tsebetso ea lik'hemik'hale ho eketseha mali ka lebaka la isoenzyme masapo. Ka halofo ea bobeli ea bokhachane le pelehi ka mafolofolo eketseha le ho timetsoa ha placenta ho bakela ho eketseha ha ea mahloriso ea isoenzyme placental.

Eketsa ea mahloriso tsa phosphatase alkaline ka mali hangata e ngolisitsoeng ka bolwetse ba sebete 'me masapo. tshenyo Parenchymal sebete bakang keketseho hanyenyane mosebetsing potlakisang tsebetso ea lik'hemik'hale ho serum mali, e le phosphatase alkaline amanang le lera la seleng. Ka tlelenike isoenzyme hepatology sebete ke e bontsha gore go bakeng sa fumanoe tsa cholestasis. Sena ke ka ntlha ya go eketseha tswakana ba bile difapho lisele tse AP le tlōlo potlakisang tsebetso ea lik'hemik'hale ho itšehla thajana ka bile. Hyperenzymemia ke haholo-holo phahameng nakong ea ntshetsopele ya thulaganyou e pathologic le bile stasis ka sebete bile ducts. Joale e ntan'o ba mosebetsi enzymatic tsa phosphatase alkaline ka serum mali e ile ea eketseha tenfold. Ha tšenyo intrahepatic biliary potlakisang tsebetso ea lik'hemik'hale mosebetsi ka eketseha mali makhetlo feela 2-3. alkaline phosphatase ntho e tloaelehileng bakeng sa batho ba baholo ho fihlela ho lilemo tse 31 ba etsa 39,0-92,0 iappa / L ka mor'a lilemo tse 31 - 39,0-117,0 iappa / L. Alkaline sekhahla phosphatase ka bana ba ka tlaase 10 lilemo - 106,0-213,0 iappa / L ho dilemo tse 3 - 71,0-213,0 iappa / k, 'me bakeng sa masea - 35,0-106,0 iappa / L.

Ka bolwetse tsa lesapo, ha ho na e eketsehileng mosebetsi oa osteoclasts, nakong ea ho hōla ha rickets, osteodistorofii, hyperparathyroidism maling eketsa mosebetsi oa phosphatase lesapo alkaline. Tabeng ena, kakaretso ea alkaline phosphatase mosebetsi maling ea eketseha ka makhetlo a 3-10. Bakeng sa fumanoe ba pele ba rickets le osteodystrophy ke keketseho e itseng mosebetsing phosphatase ka mokelikeli mokelikeling. Keketseho ea mosebetsi alkaline phosphatase ka mokelikeli cerebrospinal ke pontšo ea ho hlōloa ha lera la neuronal, moo e localized.