Lisireletsi ho DNA habeli-tsielehile - haholo-holo ditlwaelo le tshirololo

Anti-dsDNA (antiDNK) kapa habeli-tsielehile lisireletsi DNA ke heterogeneous sehlopha sa lisireletsi khahlanong le DNA habeli-helical, hammoho le ka batshwai laboratori ea la sle la (systemic lupus erythematosus).

Autoantibodies khahlanong le DNA, tse teng ka hara khubung ea bitsoang lisireletsi ho DNA habeli-tsielehile. Sesosa hantle ha e so fumane maling.

ke eng e antibody?

The sesole sa 'mele oa motho ho hlahisa lisireletsi, seo ho thoeng ke liprotheine tse ikhethang tseo loantša likokoana-hloko tse sa tšoaneng, likokoana-hloko, li-fungus, libaktheria, ke hore, le likarolo tsoang linaheng tse ling ka boemong ba liphatsa tsa lefutso. mosebetsi oo o akarelletsa ho antibody efe kapa efe ho senya lintho tse bonahalang tsoang linaheng tse ling 'me ha a tšoara lisele letsoalloa, ba bitselitsoeng ho intša mamello mochine.

Ho na le Maemong a ha e le karabelo boitshireletso e lebisitsoe lisele tsa sona 'me lisele tse, ha linaheng tse ling. Joale ho na le tsoelo-pele ea lefu e autoimmune, le lisireletsi hlahiswa khahlanong le lisele tse ea eona e le dikarolo tsa bona, litsebi li bitsoa autoimmune.

Ha ketsahalo ea "ho hloleha" e tebileng ea maloetseng, e ile ea eketseha maemo a autoantibodies, e ho lekane haholo bakeng sa staging ho fumanoe ba le mamello.

Lisireletsi ho DNA habeli-tsielehile - antibody ha e mong, empa ka kakaretso fapaneng ya bona, e leng DNA shebiloeng seleng ea khubu.

Antibody liteko e ela hloko haholo bakeng sa fumanoe tsa sle la, ke hore,, ka lebaka bo botle bo ka bua ka netefatso ya tepelletse maikutlong ka. Ka 70-80% ea linyeoe, bakuli ba khetholloa ka ho toba and analysis ena. Leha ho le joalo, ka lebaka la ho nahanela lekaneng ea ho etsa lipatlisiso e hloka tlhokomelo e moholo ha ho bala diphetho teko, joalokaha eka seo se mpe, ho ke ke ha e le hantle hore ho ba le mamello ha a na sle la.

metsoako tsena hangata e ba khethiloeng rheumatologist. Empa ho ka ngotsoe tataiso le ngaka e thusang batho, 'me nephrology,' me letlalo. Tsohle e tla itšetleha ka seo setsebi a bua le mamello qalong. Immunological laboratori ea - sena ke sebaka, moo a ileng a ba khannela lipatlisiso ka antibody ena. ho lokisetsa e khethehileng bakeng sa and analysis ha ho hlokahale.

Sle la - systemic Lupus Erythematosus

Sle la ke e tebileng autoimmune lefu e amang tsamaiso ea multiple lekala (tsamaiso ea boko, letlalo, liphio, manonyeletso, methapo ea mali le pelo). Ho ba teng tsoa hong matšoao ka 'mele kaofela e sa ho hlokeha. Liponahatso tsa lupus tse fapa-fapaneng haholo: Monna e mong o tla hlōla le matšoao a letlalo, ho tse ling tse, ho etsa mohlala - a liphio.

Lisireletsi ho DNA letsoalloa habeli-tsielehile tla thusa ho hlwaya lefu lena.

lintlha kotsi bakeng sa systemic lupus erythematosus

• liphetoho hormonal (pelehi, bokhachane, ho ilela khoeli), e phahamisa prolactin le estrogen bananeng, e hlalosang ka tekanyo e phahameng ea 90% ya mafu har'a basali.
• A predisposition ho boemong ba liphatsa tsa lefutso, e leng se tiisang hore ho ba teng ha beng ea bakuli ba nang le sle la maemo tlaase ea antigens itseng oa tsamaiso Hla le autoantibodies.
• Lithethefatsi - "methyldopa", "Procainamide," "Hydralazine".
• tshwaetso bongata ba kokwanahloko ho etsa hore le thulaganyo autoimmune.
• mahlaseli a letsatsi (mahlaseli mahlaseli bakela lisele tse letlalo ho apoptosis bare DNA, 'me e ba bonahalang ho boitshireletso ba mmele).

Ho hlahloba lisireletsi ho DNA habeli-tsielehile ke rutang haholo.

symptomatology tsa sle la

makgetheng le tloaelehileng la liponahatso ka 'na sa bitsoa ruruha lisele tsa mmele nodes, bofokoli le mokhathala, feberu, boima ba' mele, bohloko e kopanetsoeng, 'me mesifa.

• Lupus nephritis kapa ho hloleha renal (a liphio mosebetsi le fokotswa ho na le o rapeloang ka boraro matšoao laboratori ea).
• Ramatiki le arthralgia, a etsa hore ho ruruha le soreness ka manonyeletso ba manonyeletso ba, matsoho, e leng bontša e le phokotso X-ray a segokanyipalo lesapo pota kopanetsoeng (periarticular osteoporosis), Leha ho le joalo, a ke ke a erosions.
• Serositis, ke hore ho ruruha ea lera serous tsa pelo le matšoafo (pleurisy, pericarditis).
• Photosensitivity, a etsa hore a ntseng a mpefala matšoao mor'a ho pepesehela letsatsing.
• Lekhopho, ho akarelletsa le ka sefahleho, le lekhopho serurubele. Lisireletsi ho DNA habeli-tsielehile di fumanwa ho hlokahala.

• nephritic lefu - 45-65%.
• Nyenyane hematuria - ho ba teng ha 80% ea lisele tse khubelu tsa mali a ka lake sediment le moroto.
• Proteinuria e amanang le ho lahleheloa ke protheine ka moroto wa ka bophahamo ba modumo moholo ho feta 0.5 g, / s, i.e. 100%.
• seoelo haholo ka moroto bohlokoa palo ya leukocytes (pyuria), haholo-holo ho ba sieo ha tšoaetso ea pampitšana mosese.

• Retina k'hothone-joaloka lipokothong thehoa hape swells le papilla optic.
• Ho ba teng ha a hlobaetsang lupus pneumonitis, tšenyo ea matšoafo, ho khohlela le feberu kamanong le spotty alveolar khukhuneloa.
• Liponahatso tsa maemo neuropsychiatric ho tloha ho tepella maikutlo le ho ipolaea le paroxysms epileptiform, psychosis le impairments bonwang.

Ha ho hlwaya mokuli le lisireletsi sle la ho DNA habeli-tsielehile hlokahala ka pheta taolo likhoeli 1-3-6-12. Ho itšetlehile ka ho tiea tsa lefu lena. Ka bakuli bana ho eketsa kotsi ea tshenyo a liphio, hobane antiDNK mehahong le mehahong boitshireletso lebisa tshenyo liphio.

Analysis antiDNK

and analysis ena ke ho hlokahala hore:

• Ho noha katleho kalafo.
• Ha belaelago ke na le systemic autoimmune lefu.
• Ha ka lebaka la ENA antibody batlisisa positive, lisireletsi antinuclear.
• Ha matšoao a sle la ba le teng.
• Ha belaelloa ba teng ha lefu le systemic, haholo-holo sle la.
• Bakeng sa differential phumano ya lefu articular.
• Ha sephetho teko e-positive antinuclear antibody.
• Ho bolela esale pele ntshetsopele ya tshenyo liphio.
• Ho laola phallo ea chelete ka thata.

Ho etsahala'ng ka motho ea ha a ne a hōlisitsoe lisireletsi ho DNA habeli-tsielehile?

Symptomatology ho beha antiDNK

• E ile ea eketseha 'mele mocheso, lisele tsa mmele nodes, fokotswa boima, mokhathala bonahala.
• Ramatiki, ho ruruha ha manonyeletso, o ile a bontša ho ruruha, bohloko feberu sebakeng sena, reddening tsa letlalo 'me a tsamaiso ho hloka taolo.
• Ha atypical matšoao a mafu a kelello 'me methapo ea kutlo.
• Ha pleurisy kapa pericarditis se hlahang ho yona e sa tsejoeng.
• Ha lefu Raynaud e, ke hore,, ho fetola nako le nako ka 'mala oa menoana (redness, palo, e putsoa), tlōlo ea nahanela bona le bohloko.
• mafu a liphio nang le sephetho sa 'mele kapa ho Genese liphetoho moroto and analysis (hematuria, proteinuria).
• Ha matšoao a letlalo - thickening ea letlalo la, rashes, haholo-holo ka mor'a sunbathing.
• Haemolytic khaello ea mali, ho timetsoa ha lisele tse khubelu tsa mali methating e phahameng ea bilirubin ka moroto le mali.
• Ha neutropenia, fokotseha neutrophil leukocyte moralo.
• Ha thrombocytopenia, fokotseha ha palo ea li-platelet tsa mali.

Lisireletsi ho DNA habeli-tsielehile: tloaelehile

Ka tloaelo, ka lebaka and analysis e lokela ho ba mpe, 'me ea mahloriso ea 0-25 iappa / ml tse.

Ha sephetho se nepahetseng, re ka re: mathomo biliary ho thatafala ha sebete; sle la; tšoaetsanoang mononucleosis; kalafo katleho (sle la ka kokobetse); foleng lefu la sebete B le C; lefu Sjögren ya; tsoakiloeng connective dinama tse nyenyane tse maloetse.

Habeli tsielehile DNA le lisireletsi (IgG le IgM immunoglobulins) theha e rarahaneng 'mele. O etsa hore ba bang ba le matšoao a khethollang ea sle la.

Ha sephetho se mpe, bua ka lupus lithethefatsi kapa ba sieo ha ea SCR.

Eo e ama lebaka la and analysis joang?

• Phahameng ditefello antiDNK amanang le lupus nephritis, exacerbation ea boloetse kapa ho hloka matla a ho laola lefu lena.
• Tlaase ditefello antiDNK amanang le ho atleha ha phekolo le katleho ya ho ba sethaleng sa kokobetse lefu.
• AntiDNK sle la ke pontshi itseng, empa ka 'na la hlaha hape ka mafu a mang a (autoimmune, sa foleng hepatitis C le B).
• Ha antiDNK na, sena ha se tsa kgetholla phumano ya sle la.
• Bonoa antiDNK mamello ntle matšoao le dihlahlobo tse ling tsa lefu lena le ha e tšoaroa ka mohau oa ho beha ho fumanoe ba sle la.

Notices bohlokoa

Teko ea mali bakeng sa lisireletsi ho DNA habeli-tsielehile e neng e tšoaretsoe ka kopanelo le lithuto tse latelang:

• beta-2-microglobulin;
• kakaretso and analysis mali;
• antitsentromernymi lisireletsi;
• kakaretso moroto and analysis;
• antigistonovymi lisireletsi;
  

• Sebete mosebetsi liteko (alkaline phosphatase, bilirubin, GGT, AST, Alt);
• Revmoproby (ASO, C-arabelang protheine, ruruhisang Ntlha e, erythrocyte sedimentation sekhahla);
• tsitrullinovomu antibody peptide (-ba khahlanong le CCP);
• lisireletsi Antinuclear (ANA). Na autoantibodies fetisisa hantle-o ile a ithuta hammoho le ntlha e ruruhisang. Ho ile ha sibolloa ka 1957, 'me ka nako e tšoanang, bafuputsi ba proven le kamano le sle la. Ka tsela eo lisireletsi ho habeli-tsielehile DNA kgothaletswa;

• -ba khahlanong le SSB le-ba khahlanong le SSA lisireletsi;

• -ba khahlanong le SCL-70 lisireletsi;

• -ba khahlanong le nRNP lisireletsi;

• -ba khahlanong le SM lisireletsi;
• -ba khahlanong le sp100 lisireletsi.

Tse pedi lintlha tse mabapi antiDNK

Ho phaella moo, antiDNK bonahala maling ka lebaka la ho mabaka ana a latelang:

• multiple myeloma;
• Sle la tepelletse maikutlong criterion ea tsona e le hore a fumane se tsamaele hantle oa ho etsa lipatlisiso;
• pravovirusnoy tshwaetso;
• lithethefatsi inutsirovannoy sle la;
• HIV;
• lefu Sjögren ya;
  
• cytomegalovirus tshwaetso;
• Sharp lefu (tsoakiloeng connective dinama tse nyenyane tse lefu);
• tšoaetsanoang mononucleosis;
• ramatiki;
• mathomo biliary ho thatafala ha sebete;
• systemic sclerosis;
• hepatitis C kokoana-hloko;
• bongata ba kokwanahloko lefu la sebete B.

Ka hona, mali bakeng sa lisireletsi ho DNA habeli-tsielehile nka hangata.