"Endoxane": litaelo bakeng sa ho sebelisoa, counterparts ea sebele, moetsi

Lithethefatsi "endoxane" le bolela sehlopha sa baemeli ba-ba khahlanong le hlahala. Ho itšetlehile ka mofuta o sa tokollo e ka tsamaisoa ka molomo kapa parenterally. Mofuta ofe lithethefatsi le beha le ka litekanyetso li behoa ke eng, rarolla ka ngaka feela ka lebaka la maemo a sebele boemo ba mokuli.

Ea ho hlophisoa le thepa ya moriana

Ba ka sehloohong a sebetsang a motsoako oa lithethefatsi "endoxane" litaelo bakeng sa ho sebelisoa e bua ka cyclophosphamide. Letlapa le leng e na le 50 mg, ea eona. moriana o bua ka sehlopha se seng sa lithethefatsi antitumor le ke matlapa biconcave ka enfelopo e tšoeu le ea mantlha ea 'mala o tšoanang. dikarolo ka tlatsetso a sebetsang a meriana sehlahisoa se se akaretsang k'halsiamo carbonate le phosphate hydrogen, sodium karamellozu, glycerol, edible gelatin, lactose, starch poone, macrogol, magnesium stearate, polysorbate, sucrose, talc, silica le thaethaniamo.

ke pharmacology ya moriana eng?

Ba ka sehloohong a sebetsang a lithethefatsi ntho, e leng cyclophosphamide, alkylating 'me o na le phello cytostatic. Ka tlhaho lona, e le haufi le khase ea mosetareta, naetrojene ho manaka a eona.

The mochine ea nkang khato ea cyclophosphamide thehiloeng sebopeho sa crosslinks pakeng limolek'hule DNA le RNA le protheine tswakana hatella 'mele.

The pharmacokinetics ya moriana

Ba ka sehloohong a sebetsang a motsoako "endoxane" lithethefatsi na lengolo la hoo e ka bang ka ho feletseng absorbability pampitšaneng gastrointestinal. mahloriso lona ka mali ka mor'a tsamaiso molomo le intravenous aa tšoana. Cyclophosphamide metabolism le hlaha haholo-holo ka sebete, moo le tlas'a tšusumetso ea mochine microsomal dihydrobenzophenanthridine ke sebopeho sa motho ea mafolofolo alkylating metabolites. Ba bang ba bona ba fetoloa liforomo khathetseng moeeng, sehlopha se seng se fallela lisele tse, moo bohato enzymatic tsa phosphatases fetoloa dintho le thepa cytotoxic.

Tekanyo ea ho kopanya libuka tsa foromo ea pele ea lithethefatsi le liprotheine mali e hlokomolohuoang le ke 12-14%. Leha ho le joalo, le bontša e tšoanang ea metabolites se lekana le 60%.

cyclophosphamide hlahisoang ke excretion renal hangata ka mokgwa wa metabolites. Hoo e ka bang 5-25% ea lithethefatsi e excreted foromo ka eona qalong ea moroto le bile.

Paramethara T1 / 2 lithethefatsi lekana lihora tse 7 tsa batho ba baholo le lihora tse 4 bakeng sa bana.

Ka seo lethal dose ho nka moriana?

Lithethefatsi "endoxane" foromo Letlapa nkiloeng ka molomo pele lijo kapa halofo ea hora ka mor'a ho ja, ka mor'a lihora tse 2.

Ka lebaka la 'nete ea hore sehlahisoa meriana akarelletsa palo e kholo ea regimens chemotherapeutic, tlhopho Mokhoa oa tsamaiso le litekanyetso li behoa ngaka nkoa ka bomong.

"Endoxan" - Letlapa - tataiso e khothalletsa ho litekanyetso li behoa 1-3 mg, / lik'hilograma boima ba 'mele ka letsatsi, e ka ba ho tloha 50 ho ea ho 200 mg, cyclophosphamide bakeng sa lihora tse 24. Ka nako ea phekolo ke libeke tse 2-3.

Ha ea lithethefatsi e nkiloeng hammoho lithethefatsi tse ling tse nang le thepa ea-ba khahlanong le hlahala, le litekanyetso li behoa ea likarolo tsohle tsa phekolo undergoes khalemelo.

Na ho na le ba le overdose?

Ho ba teng ha ka pheko ea itseng ka ho lokisetsa "endoxane 'litaelo bakeng sa tšebeliso e sa tiisoa. Tabeng ea feteng le lethal dose a lakatsa khothalletsoang hore phekolo tokiso ka kalafo loketseng mafu a tšoaetsanoang, a khaotsa ho tsuba le matšoao cardiotoxicity le myelosuppression felisoa.

E le moriana o ho kopantswe le lithethefatsi tse ling?

Ha mokuli a nka mokhoa susumelletsang motho microsomal ho kena moea ka sebete, ka nako eo a kopaneng kalafo le moriana "endoxan" thuto e bontša eketsehile ka makhetlo tswakana tsa metabolites le mosebetsi alkylating, fokotseha halofo bophelo ba cyclophosphamide le eketsa bokgoni lona.

lithethefatsi ena thibela mosebetsi cholinesterase le tshilong ya dijo ka tseleng k'hok'heine, eketsa toxicity lona, 'me se eketsa ka bokgoni ba ho suxamethonium.

Ha "endoxane" sebelisoa ka kopanelo le "Allopurinol" hore ho na le e eketseha liphello tsa eona tse mpe ka moko oa masapo.

Tabeng ea kalafo tsoa hong le cyclophosphamide, colchicine, probenecid, sulfinpyrazone ngaka hangata khalemela lethal dose lithethefatsi-ba khahlanong le gout. Ena e amanang le kotsi e ile ea eketseha ea nephropathy ka kopanetsoeng kopo "endoxane" le lithethefatsi uricosuric.

Cyclophosphamide fokotsa tswakana lintlha ka sebete, ba na le boikarabelo hoama mali le ho hlahisoeng platelet, Leha ho le joalo, ha a ntse kalafo le anticoagulants decreases mosebetsi oa bobeli.

Bakuli ba etellang lithethefatsi "endoxan" taeo pukwanana khothalletsa lijo tse sa kenyeletswe grapefruit lero, kaha e na le metsoako e khahlanong le Tshebediso ya bokgoni le ka sehloohong a sebetsang a motsoako oa moriana o le.

Ha Co-tsamaisoa ka cyclophosphamide "Doxorubicin" kapa "daunorubicin" e Amplified litla cardiotoxic ea lithethefatsi tsena li ka.

Hammoho le oa immunosuppressants tse ling, tse kang "Azathioprine" "Tacrolimus", "Chlorambucil", "SSC", "Merkapturin" isang ho eketseha ka ketsahalo ea tšoaetso ea mahareng le mofuta hlahala.

Tabeng ea tšebeliso kopanetsoeng "endoxane" le "Lovastina" bakuli ka pelo transplantation e ka ba kotsing ea ho rhabdomyolysis le ho hloleha renal ka foromo hlobaetsang.

Ha kalafo ka cyclophosphamide kopantswe le mielosupressantami kapa le phekolo mahlaseli, ho ka etsahala hore ba fumane ugneeniya lesapo moko mosebetsi.

Tsoa hong ho amohelloang "endoxan" le cytarabine phahameng-lethal dose nakong manipulations tsa go baakanyetsa ho lesapo moko transplantation eketsa ditiragalo tsa cardiomyopathy bolaeang.

Joang lithethefatsi ena ka mosebetsi le bana?

Lithethefatsi "endoxane" Testimonials mamello ipaka e, ka qholotsa nyopa ka bakuli ba sexes bobeli, e ka ba etsolloa.

Maemong a mangata, basali amenorrhea le hlaha, empa matsatsing kamehla hangata hlaphoheloa ka mor'a likhoeli tse seng kae ka mor'a kalafo le cyclophosphamide. Ha phekolo e ile etsoa banana ba prepubertal, bopengwi ka ntshetsopele ya mahareng liponahatso thobalano li ne li hlokomela. Ho ilela khoeli e ne e le ntho e tloaelehileng, tsoalo ile lahlehile.

Ka ho phekola e motona lithethefatsi "endoxane" taeo e bontša hore ka linako tse ling li ne li tlalehile azoospermia kapa oligospermia. Sena ke ka ntlha ya go ho hlahisa tse eketsehileng tsa gonadotropins ka lebelo la testosterone ho lokolloa. libido boemo ba le potency banna e sa fokotsehile. Ha kalafo ka cyclophosphamide hlahiswa bashemaneng prepubertal, ho obazovanie mahareng liponahatso thobalano li hlahile tsela e tloaelehileng. Leha ho le joalo, maemo a ho azoospermia, oligospermia le ntlafatso ya gonadotropins li hlokometsoe. Ho ka boetse ha etsahala lekwalata felloa ke matla. Ke habohlokoa ho hlokomela hore azoospermia ke reversible, le hoja a hlaphoheloe oa mesebetsi e ka etsahala nakong ea lilemo tse 'maloa ka mor'a hore qetellong ea phekolo.

ke litla-morao tsa lithethefatsi ka eng?

Ho noa meriana "endoxane 'litaelo bakeng sa ho sebelisoa e tiisa, e ka' na ea etsa hore ba bang ba mafu a ea tsamaiso hemopoietic:

• Leukopenia, neutropenia - hangata.
• Ka tlase ho tloaelehile hore batho ba khaello ea mali le thrombocytopenia.

Ka mor'a libeke tse 1-2 ho tloha qalong ea kalafo, mokuli a bontša phokotsong palo e kahodimodimo ea leukocytes le liplatelete ka mali. entsprechen tsena di khutlisetsoa ho tloaelehile nakong ea matsatsi a 7-10 a qetellong ea phekolo.

Ea ho phekola le cyclophosphamide ka etsa liphetoho lehlakoreng pampitšaneng ena gastrointestinal:

• Ho nyekoa ke pelo le ho hlatsa.
• Anorekisya.
• Stomatitis.
• Bohloko le sebakeng ka mpeng.
• Setuloana irregularities.
• Nyooko.
• Hemorrhagic colitis.

Seoelo etsahala sebete ho se sebetse amanang le eketsehile ka makhetlo mosebetsi oa enzyme le maemo bilirubin tsoha. Haholo le sehlopha se seholo sa bakuli ba nang le aplastic khaello ea mali le ho fumana phahameng-lethal dose "endoxane" kapa kopantseng ka busulfan, o re endoflebit methapong e amanang le sebete. ketsahalo ena ka etsahala libeke tse 1-3 ka mor'a lesapo moko transplantation le e bontšoa ka ho ba le keketseho e bohale 'meleng boima, ascites, hepatomegaly le hyperbilirubinemia, e amanang le sebete magazine.

Pele lithethefatsi ho ka baka liphetoho tse sa rateheng ka letlalo:

• Reversible alopecia.
• Lekhopho.
• The pigmentation tsa letlalo 'me a lipekere.

E le ka boela ea tsosa ke tlōlo ea tsamaiso ea mosese ea ho phekola ba lithethefatsi "endoxane". Litaelo, ulasan pelanggan tsa lingaka le bakuli ba ho bontša e re fapaneng:

• Cystitis hammoho le ho senya fibrosis (kapa ka ntle ho eona).
• Hemorrhagic urethritis.
• liketsahalo Necrotic tubule ho fihlela lefu.

Ka moroto, mamello ea ka 'na ho lemoha ke epithelium tsa senya mosese. Ha mofuta o oa hemorrhagic cystitis boima, emisa etellang lithethefatsi. Ho thibela ho fetisisa boemo ena ke meriana "Mesna". Ha "endoxan" lethal dose e eketseha, ka ba le a liphio ho se sebetse ka nephropathy le giperurekemii.

Ha mokuli a se na le lengolo la e mpe ea 'immunosuppression, ka nako eo ho phekola cyclophosphamide ka ba le tšoaetso ea matla.

Hape ka ba le liphello tse latelang lehlakoreng:

• Cardiotoxicity (phahameng tekanyetso), lengolo la e mpe ea 'ha pelo.
• Methapo fibrosis, interstitial tlhaho.
• Qhala spermatogenesis le oogenesis, reversible le etsolloa nyopa.
• Ntshetsopeleng ya neoplasms mahareng bolaeang kang kankere ea e senya, mieloproliferatsiya le lymphoproliferation.
• Allergy ka lekhopho, ho hlohlona, urticaria, ka linako tse ling ka mokgwa wa e itsoara joang anaphylactic.
• Empa mafutsana leqeba pholiso.
• Sefahleho e phallang, ho fufuleloa, hlooho.

Boteng ba litla bo tebileng boo lehlakoreng ho etsa lithethefatsi ba kamehla hlahisa potso ka melemo ea khoneha khahlanong le likotsi tse khoneha bakeng sa mamello motho.

Eo mafu a ho laela lithethefatsi ee?

Tablets "endoxan" ka abeloa ho ea ba le mamello ha o na le mafu a latelang:

• lefu Hodgkin e.
• Multiple length myeloma.
• kankere ea matsoele.
• Na le lymphoblastic lymphoma foromo hlobaetsang kapa le sa foleng.
• Bao e seng Hodgkin o lymphoma mofuta.
• Retinoblastoma.
• Neuroblastoma.
• Mycosis gribkovidnogo botho ba hae.

Ho bontsha kamogelo ya kopo le ka rarahaneng anticancer phekolo khomaretse lithethefatsi "endoxane" taeo. The moetsi e khothalletsa hore ho kenyeletsa ho phekola kankere cervical le kankere senya, kankere ea matšoafo le kankere ea tšoelesa ea senya, sarcomas le reticulosarcoma, mafu Ewing le Wilms.

The cyclophosphamide thehiloeng lithethefatsi li ka sebelisoa e le mafu a immunosuppressant tsoelang pele autoimmune joaloka, psoriatic le ramatiki, haemolytic khaello ea mali, mafu collagen, lefu nephrotic, hammoho le ho qoba palaeform khesoa.

Ha ea lithethefatsi e contraindicated?

The moriana o "endoxan" e na le boima contraindications ho, ho akarelletsa le:

• Boimana le diabolololo.
• Cystitis.
• Tsoaetsanang ka mokgwa mafolofolo.
• Tlōlo ea tshebetsong lesapo moko bitsoa foromo.
• Ho ba teng ha hypersensitivity tsa motheo le tlatsetso dintho lithethefatsi.
• mosese tshegetsa le go tlotla.

Special tlhokomelo lingaka ho laela lithethefatsi ka mafu a ba pelo, liphio le sebete, matla, gout, adrenalectomy, boteng ba dithulaganyo khukhuneloa ka moko oa lesapo, nefrourolitiaze.

tataiso e itseng ea ho phekola ba

Nakong-ja "endoxan 'tlas'a taolo ea mali e tlamang (neutrophils le pleitelete) le moroto (ho ba teng ha lisele tse khubelu tsa mali a) a le mamello.

e kgothaletswa ho khaotsa ho kalafo "endoxane" le bolela maemong a mang. Litaelo tabeng ea ho sebelisa lipilisi kgothaletswa ho etsa joalo tlas'a maemo a latelang:

• Ponahalo litsupa cystitis.
• Theola ea mahloriso ea leukocytes le liplatelete ho makgabane e mahlonoko.
• Ketsahalo ea tšoaetso (lethal dose khalemelo ke khoneha).

Ha "endoxane" le sebelisitsoe ka tekanyetso e phahameng, ho ba le mamello e hlophisitsweng meriana, "Meena" bakeng sa thibelo ea mofuta hemorrhagic cystitis.

Ea ho phekola le lithethefatsi ena lokela ho qoba ho noa joala le ho sebelisa mekhoa e ka tšeptjoang ea pelehi.

Ha ba le mamello e abeloa "endoxan" bakeng sa matsatsi a 10 ka mor'a ho buuoa le thethebatso kakaretso, anesthesiologist e tsebisoa ka sena.

Mora adrenalectomy a etsa lethal dose phetoho "endoxane" le ho sebelisa lithethefatsi tse ling tse corticosteroids.

analogues lithethefatsi

Haeba ho na le contraindications tebileng 'me likotsi, moo e filwe ho tela etellang moriana "endoxane" taeo. Analogs ka laetsoeng ke ngaka ka mefuta e meng ea loketseng. Har'a bona:

• "Ledoksin".
• "Cyclophosphamide".
• "Cytoxan."
• "Cyclophosphamide - Teva".
• "Cyclophosphamide -Lens".
• "Endoxane - Astana".

Tlhahisoleseding ena ke tlhahiso e nolofalitsoeng ea litaelo ho lithethefatsi "endoxane". Ka morero oa ho ea lithethefatsi ena o entsoe feela ka ngaka e-ba teng.