Dehydroepiandrosterone sulphate (DHEA-S)

Dehydroepiandrosterone sulphate (DHEA-S) - androgen ke hore ka kena bonneng kapa bosaling ha amana. Tsa maiketsetso 'me secreted ke litsoelesa adrenal eona. E amana le ketosteroids dehydroepiandrosterone sulfate.

DHEA-S e tsa maiketsetso haholo ea k'holeseterole Ester sulfate. Palo tsa motheo tsa androgen catabolized me, ha e le busa, ba etsang liphesente tse leshome feela excreted ka moroto wa.

Dehydroepiandrosterone sulfate e sa amanang le liprotheine itseng ka lero la mali mali, ka lebaka leo, ea mahloriso ea bona ka boemo ba DHEA-S e sa ameha. Leha ho le joalo, ka steroid tlama ho albumin ka serum.

Ho phaella ho DHEA-S ka ho hlophisoa ha mali e potoloha kenyeletsa dehydroepiandrosterone. Karolo ea sebopeho ea eona e leng cortex adrenal le hlaha mokhoa o sa fellang - gonads. Hobane metaboliki rengwa DHEA ka potlako haholo, mahloriso tsa lona ka ho ipapisa le DHEA-C ka tlaase mona.

Ka lebaka la ho concentrations phahameng tsa dehydroepiandrosterone sulfate, botsitso phahameng le e telele halofo bophelo, 'me ha e le hantle hore mohloli oa lona, ka nako e ngata, ke adrenal steroid ke pontshi e babatsehang ea secretion androgen.

Ntle le cortex adrenal ka banna ba sa reng letho ka karolo (5%) e hlahisoa gonads ena. Ho basali ba, ba mae a bomme ho hlahisa ka ho na le. Ea mahloriso ena androgensinteticheskuyu hormona bontša tšebetso ea adrenal ena. Dehydroepiandrosterone sulphate na hanyane androgenic mosebetsi. Leha ho le joalo, nakong ea metabolism tsa lona, e leng le hlaha ka lisele pheriferale, ya hlahiswa dihydrotestosterone le testosterone.

DHEAS rengwa sekhahla tlaase. pontshi ena e sebelisitsoeng ka eona ka phumano ea linaha hyperandrogenic etsahalang basali. Tsena li akarelletsa alopecia, hirsutism, le bokuli bo itseng ba mosebetsi le ho hlahisa bana. Ka tsela eo hyperandrogenism ka 'na na le hlahang ho yona popelo kapa adrenal. Kahoo, litlhahlobo endocrinological qala ka qeto ea mahloriso ea dehydroepiandrosterone sulfate le testosterone. Eketseha litsupa bona bontša hyperandrogenism se hlahang ho yona adrenal. Ho phaella moo, ka tekanyo sebelisoa ka lekola boemo ba androgens ka semelo sa tieho ntshetsopeleng thobalano.

Ho pholletsa le ho ima ho, tlhahiso ea sulfate dehydroepiandrosterone le hlaha ka cortex ea litsoelesa adrenal tsa lesea le 'me. Bakeng sa tswakana tsa estrogens ka placenta ho ke homone selelekela.

Ka basali ba baimana, dehydroepiandrosterone sulfate mahloriso ka mali decreases tekano. Ke nako ea ho kena bonneng kapa bosaling ho bana boemong ba eketseha ea hae, joale butle-butle decreases le lilemo.

Dehydroepiandrosterone sulfate phahameng ka ho:

- congenital adrenal hyperplasia;

- lefu (lefu) Cushing ;

- lihlahala tsa cortex adrenal (maemo a bolaoa ke kankere ka a phahame ho feta adenoma);

- polycystic ovary lefu ;

- lihlahala ektopichesoky lihlahisoa;

- verilnom lefu.

Fokotswa hormona mahloriso o ile a re ka:

- se mahareng le mathomo adrenal insufficiency;

- bokhachane;

- sa mathomo hypogonadism (faola, Klinefelter ya lefu) tseo e leng banna;

- hypogonadism mahareng (pituitary) ka basali;

- molomo lithibela-pelehi;

- pangipopituarizme;

- osteoporosis.

Dehydroepiandrosterone sulfate, tekanyo bakeng sa banna ba lilemo tse 21 ho tse 39 tsa 1,0-4,2 g, / ml tse, bakeng sa basali tloha ka ba lilemo 19 ho 39 lilemo li - ka, 8-2,9 g, / ml tse.

Methating e phahameng ea testosterone basali hlalosang DHEA-S mahloriso ka ho ikemisetsa hore na boemo ba boloetse bo amanang le lefu le popelo kapa adrenal. dehydroepiandrosterone sulfate boemo ba litsupa feela ha eketseha pathologies adrenal. Tsena li akarelletsa, ka ho khetheha, e kenyeletsa lihlahala, hyperplasia le maloetse a mang.