4 (mahala): ntho e tloaelehileng. Hormone T4 (mahala): ho hlahloba mali bakeng sa li-hormone thyroid

Le ea bohlokoa haholo ka ho ea ka tšebetso e tlwaelehileng ya thyroid tsoelesa e ke hypothalamic-pituitary thyroid tsamaiso. E fana ka taolo ya tswakana tlhahiso, 'me mosebetsi oa li-hormone thyroid.

Overview

The hypothalamus ntša mafura (tireotro-Pin-ho lokolloa Ntlha e). E, le eena, di hlohleletsago ho lokolloa le tswakana ya thyroid Stimulating Hormone (TSH - TTG). TSH ho akarelletsa dithulaganyo le amanang le steroid tse ling. Ka ho khetheha, ho di hlohleletsago secretion, bokella, metabolism le tswakana tsa triiodothyronine (T3) le thyroxine (T4). Tse fetang 99% ea steroid tsena tse peli tse maling e potoloha ka amanang liprotheine lipalangoang foromo. ba etsang liphesente tse ka tlase ho e 'ngoe ke ka ho mahala foromo. Mollwane maemo steroid ka batho ba bangata ba e ya kokangana pusong tshebetso ya thyroid tsoelesa e.

thepa thyroxine

Hormone T4 (mahala) ntsetso-peleng molao oa tsamaiso ya kgolo ho tloaelehile le ntshetsopele, ho etsa bonnete ba ho boloka mocheso oa 'mele le tsela eo ho boloka mocheso buildup. The komponeng e na le phello e mekhahlelo kaofela k'habohaedreite metabolism, e sa fella - ho vithamine le lipid metabolism. Hormone T4 (mahala) ke ea bohlokoa karolo ea ntshetsopele ya bokgoni ho utero le linako neonatal. mahloriso a bontša boemo ea tleleniki ea boemo thyroid, e le phetoho ka boemo kakaretso ea thyroxine ka bakoa ke meferefere ka mosebetsi oa thyroid tsoelesa kapa phetoho e palo ea liprotheine lipalangoang. Motšehare, ho dikahare palo e kahodimodimo ea steroid ikemiselitse ho tloha lihora tse 8 ho ea ho 12, 'me bonyane - le 23' me 3. Nakong selemo, boemo phahameng ka ho fetisisa 4 (mahala) fihla ho tloha ka September ho fihlela February, le tlaase-tlaase - lehlabula. Ka nako prenatal (nakong emara) thyroxine mahloriso e ile ea eketseha, e fihla boemong ba palo e kahodimodimo ho butle-butle boraro trimester. Ho pholletsa le bophelo ba thyroxin dikahare ka batho ba sa tsotellehe bong ntse batlang e le kamehla. Fokotswa li-hormone hlokomela ka mor'a lilemo tse mashome a mane.

Ke eng e ka bolella boemo ba thyroxine?

Ha T4 (mahala) e ile ea eketseha ka ho hlaka, joale e ho nkoa e netefatso ya hyperthyroidism. Fokotswa mahloriso bontša hypothyroidism. The boipuso tsa dikahare steroid tsa thyroxine globulin tlamang etsa ho ka khoneha ho e sebelisa e le ea tšepahalang teko tekotshupo. Sena ke haholo-holo bohlokoa ka maemo a neng a ba tsamaea le liphetoho tse ka maemo a thyroxine-tlama globulin. Tsena li akarelletsa lithibela-pelehi molomo (molomo), boimana, ho androgen kapa estrogen bananeng. Liphetoho tse bath le bakeng sa ba nang le predisposition lefa ho eketsa kapa fokotseha ea mahloriso ea globulin. A fana ka mali bakeng sa mahala T4 khothalletsoang hore mofuta phumano ya hypothyroidism mahareng ka lebaka la ho pathologies ka boemo hypothalamo-pituitary. Tabeng ena TTG dikahare ha a fetohe kapa eketseha. Ka tloaelo ho, ea maemo e phahameng ea thyroxine ne e ka ba ka lebaka la ho phahameng ea serum bilirubin, botenya, hammoho le e tourniquet, ha tla teko ea mali. 4 (mahala) ha a fetohe tlas'a mafu khōlō mosebetsi bao e seng thyroid. Boemo ba palo yohle thyroxine a ka fokotseha.

Ho lokisetsa hlahlobo ya laboratori ea

Khoeli pele ho fana ka mali beheletse ka thoko thepa le tsamaiso tsa tsa-hormone (ntle le haeba ho na le litaelo tse tobileng endocrinologist). Matsatsi a mabeli kapa a mararo ho thibela ho sebelisoa ha ho hlahloba lithethefatsi a iodine litareng e-nang le. Mali lokela ho feta pele ho lithuto tsa radiological sebelisa fapana le likokoana-hloko. Bosiung ea ho fana, mali a lokela ho qoba ho ikoetlisa, felisa maemong a sithabetsang. Pele ho thuto, halofo ea hora, o lokela ho kokobela, leo bakela ho hema ho tloaelehileng. and analysis e phethile ka mpeng letho. Le lijo ho qetela e lokela ho ba seng ka tlase ho lihora tse robeli (empa ka go tlhaolega 12 lihora tse). Ho e sa lumelloa ho noa kofi, tee kapa lero. Ka metsi feela.

Fokotswa maemo tsa thyroxine

4 (mahala) (tloaelehile basali le banna ba - 9-19 pmol / l) ka fokotswa ka nako postoperative, ha hypothyroidism mahareng (ho ruruha ea pituitary, tireotropinome, lefu, Sheehan). Fokotsa ea mahloriso e boetse e ile a re ka lebaka la anabolics baeti ba fihlelang, thyreostatics, lithethefatsi anticonvulsant, litokisetso lithium. Thyroxine boemo ba decreases ha u sebelisa lithibela-pelehi molomo, octreotide, methadone, clofibrate. bakang khoneha hape e kenyeletsa lijo le chelete e fokolang ea protheine, khaello a iodine litareng e, tšebeliso heroine, kgahlamelo ya maqhubu a ho etella pele. 4 (mahala) o ka fokotswa ka phahameng (methapo ea kutlo hypothalamus TBI), e fumanweng, congenital hypothyroidism (har'a resection e pharaletseng tsa hlahala le thyroid, autoimmune thyroiditis, tloaelehile haholo goiter).

eketseha concentrations

Boemo ba li-hormone tse kang T4 (mahala) (basali le banna ba bontša ka holimo ho tloaelehile) o ka e ile ea eketseha ha nang le chefo e goiter, TSH-ikemetseng hyperthyroidism, botenya. Eketsa ea mahloriso o ile a re ka semelo sa lefu nephrotic, heparin phekolo. Mabaka a boela kenyeletsa choriocarcinoma, baeti ba fihlelang ho ya thyroxine motheong oa hypothyroidism, poso-Natal fetola mosebetsi oa thyroid tsoelesa, boloetse bo sa foleng sebete. 4 (mahala) ka phahameng ka thyroid hanyetsa lefu steroid, liphatsa tsa lefutso dizalbunemicheskoy hyperthyroxinemia, o re, susumelletsang motho ea fokotseha tiroksinsyazyvayuschego globulin mahloriso.

Thyroxine le ho ima

hormone thyroid ameha hoo e batlang e mong le e mong a thulaganyo mele. Joalokaha ho boletsoe ka holimo, metsoako laola metabolism, ama mosebetsi oa steroid tse ling. Thyroid bolwetse ka tsamaea le bobeli ho eketseha le ho fokotseha ka mesebetsi ea eona. Le ea bohlokoa ho khetheha ka tlōlo ea mesebetsi lekala na nakong bana ba. The phetoho ya puso tshebetso ya thyroid tsoelesa e ama tsela ea bokhachane, botho ba hae, 'me sephetho sa maemo a sa tsoa tsoaloa ho. Seoelo vynashivanie fetisa ha a bolela hore endocrine pathologies. Mafu a ea mofuta ona, e le busa, lebisa ho se sebetse ho ikatisa, ho kgaolela basadi thari. Hangata ka ho fetisisa fumanoa nakong ea bokhachane goiter (ho eketseha ha thyroid diffuse mofuta) le euthyrosis polokesegong, hammoho le autoimmune thyroiditis, susumelletsang motho liphetoho ka semelo sa hormonal. Bakeng sa nako prenatal e tšoauoa ka liphetoho tse profinseng tshebetso ya tšoelesa ena.

likhothaletso

Ho ka nepo ho hlalosa liphello tsa liteko laboratori ea nakong ea bokhachane lokela ho nahana ka tse ling tsa lintlha. Boikemisetso ba palo yohle T3 le T4 hase boitsebiso bo rutang. Sena ke ka ntlha ya go ha e le hantle hore nakong ea bokhachane, ea mahloriso ea bona e ile ea eketseha ka halofo. Ha ho ithuta mollwane thyroxine boemo ba mahloriso lona lokela ho ikemisetsa ka kopanelo le diteng TTG. Thyroxine batla tse eketsehileng e ka bang ka 2% ea basali ba baimana. Ka halofo e qalang ea le tloaelehileng prenatal nako tšoauoa fokotseha TTG (hoo e ka bang 20-30% ea bakuli le singletons le maemong 'ohle a bokhachane multiple). Ka ho phekola hyperthyroidism T4 fuputswa feela (mahala). Mollwane thyroxine boemo ba ka mekhahlelo e hamorao ka marginally fokotsehile. Ka tsela eo TSH mahloriso tla lula a e mengata e fapaneng ho tloaelehile.