"Mesakol": buka ea litaelo, litlhaloso, li-analogues

Nonspecific ulcerative colitis, hammoho le lefu la Crohn , ha li fumanehe ho bakuli. Empa, ho sa tsotellehe sena, ho na le lithethefatsi tse ngata tse etselitsoeng ho phekola maloetse ana. E mong oa bona ke Mesakol. Litaelo tsa tšebeliso, foromo, maikutlo le litšenyehelo tsa sesebelisoa sena li tla fanoa ka tlase.

Sebopeho, mokhoa oa ho lokolloa, liphutheloana le tlhaloso

Meriana e bitsoang "Mesakol", eo litlhaloso tsa eona e leng tse tsotehang haholo, e ntse e rekisoa ka lipampiri tse khubelu. Li koahetsoe ka seaparo sa enteric, hape se na le foromo e chitja le biconvex.

Ntho e ka sehloohong ea moemeli ona ke mesalazine (5-ASA). Ho phaella ho eona, lithethefatsi li na le likarolo tse ling tse kang li-corn starch, calcium hydrogen phosphate dihydrate, talcum e hloekisitsoeng, microcrystalline cellulose, titanium oxide, hypromellose 2208, silicon oxide colloid, povidone K90, sodium carboxymethyl starch, methacrylic acid le methyl methacrylate acid e kopolymer, Macrogol 6000 le dibutyl phthalate.

Matlapa a "Mesakol" a hlahisoa ka lihlahisoa tsa aluminium le lipakete tsa lik'harete, ka ho latellana.

Pharmacology

Na ua tseba hore na Mesakol ke eng? Litaelo tsa tšebeliso li bontša hore sena ke setsebi se khahlanong le ho ruruha, seo ketso ea sona e leng sebakeng sa mala. Setša sena sa lithethefatsi se amahanngoa le bokhoni ba sona ba ho thibela mosebetsi oa ho qala li-leukotriene le prostaglandins, hammoho le lipoxygenase ea neutrophilic.

Hape hoa lokela ho hlokomeloa hore moriana o potsoeng o fokotsa ho falla, phagocytosis le degranulation ea neutrophils, hammoho le ho thibela li-immunoglobulins ka lymphocytes.

Ke lisebelisoa life tse ling tseo moriana oa "Mesakol" o nang le oona, theko ea oona e bontšitsoeng ka tlase? Mesalazine e na le phello ea likokoana-hloko khahlanong le li-cocci le Escherichia coli (ka maleng a maholo).

Pharmacokinetics ea lithethefatsi

Ke mekhoa efe ea kinetic ea matlapa a Mesakol? Litaelo tsa tšebeliso li bolela hore ka mor'a ho li fumana, mesalazine e lokolloa sekhethong ka mor'a metsotso e ka bang 115-165, 'me ka mor'a metsotso e 170-230 matlapa a qhibiliha.

Ka lebaka la lehare la filimi, sethethefatsi se potsoeng se lokolloa 60-80% karolong e teteaneng ea mala, le 15-30% ka maleng a manyenyane. Tabeng ena, motsoako o sebetsang o kenella ho potoloha ha systemic feela ka tekanyo ea 10% ea tekanyo e nkiloeng. Mesalazine ea maqhubu a lero la mali a tlase haholo.

Tšebeliso ea motsoako o sebetsang le liprotheine tsa plasma ke 43%. Moriana o potsoeng, hammoho le metabolites, o kenella ka lebese la matsoele.

Metabolism ea mesalazine e etsoa ka maleng le ka sebete. Sena se hlahisa N-acetyl-5-aminosalicylic acid.

Bophelo ba halofo ea moriana ke metsotso e 60-120 (ho itšetlehile ka tekanyo e nkiloeng). Meriana e fanoa ke liphio le ka maleng.

Litlhaloso tsa ho noa meriana

Mesakol o tšoara maloetse afe? Litlhaloso tsa lingaka li re pheko ena e sebetsa hantle ho phekola lefu la Crohn le lefu la ho bolaoa ha ulcerative.

E lokela ho tsejoa ka ho khetheha hore meriana eo ho buuoang ka eona e sebelisoa eseng feela bakeng sa ho phekola mafu a boletsoeng ka holimo, empa le ho thibela ho feta ha bona.

Litlhaloso tsa ho noa meriana

Ha e kgothaletswe ho fana ka meriana "Mesakol":

• Le seso sa lesapo la tsamaiso ea lijo;
• Maloetse a mali;
• Ho hlōleha ha renal;
• Hemorrhagic diathesis;
• Bongoaneng;
• Ho hloka matla haholo;
• Hypersensitivity ho metsoako ea lithethefatsi;
• Ho hloka ha glucose-6-phosphate dehydrogenase.

Ka ts'ebeliso e khethehileng, lithethefatsi ena e sebelisetsoa ho matlafala ha maikutlo a liphio ka bonolo ho isa boemong bo leka-lekaneng, hammoho le ho se sebetse ka mokhoa o itekanetseng le o bonolo.

Lipilisi tsa Mesakol: litaelo tsa tšebeliso

Moemeli ea nkiloeng o nkoa molomong feela ka mor'a hore a je.

Ha lefu lena le ntse le mpefala, le laeloa ka bongata ba 400-800 mg (ke hore, matlapa a 1-2) ka makhetlo a mararo ka letsatsi. Phekolo e phethoa libeke tse 9-12.

E le ho thibela ho eketsa matla, lithethefatsi li sebelisoa ho 400 mg ka makhetlo a mararo ka letsatsi. Matlapa a nkiloe ka kakaretso, a hlatsoitsoe ka metsi a hlakileng.

Meriana ea Mesakol e lokela ho fuoa bana joang? Melase, li-microclysters le ho emisa - ke ka foromo ena ho bonts'a lithethefatsi ho masea.

Liphetoho tse mpe

Ka bomalimabe, ho noa meriana ena hangata ho bakoa ke litla-morao. Li akarelletsa tse latelang:

• Pericarditis, tachycardia, lefu la pelo ea ho khanna, lefu la khatello ea sefuba, lefu la sefuba, lefu la sefuba, li-palptation, dyspnea;
• Ho fokotseha, ho fokotseha takatso ea lijo, ho hlatsa, ho eketseha ha lintho tsa hematic transaminase, ho otloa ke pelo, stomatitis, letšollo, lefu la sebete, mahlaba a mpeng, pancreatitis, molomo o omeletseng;
• Oliguria, proteinuria, crystalluria, hematuria, lefu la nephrotic, anuria;
• Ho ba le botsoa, ho hloohoa kelellong, ho hlokomoloha maikutlo, ho tšoaroa ke boroko, ho robala, polyneuropathy, ho tepella, ho thothomela, ho tepella maikutlo;
• Eosinophilia, thrombocytopenia, phokolo ea mali (hemolytic, aplastic kapa megaloblastic), agranulocytosis, mali a mali, hypoprothrombinemia;
• Oligospermia, ho hloka matla;
• Bofokoli, photosensitivity, parotitis, ho fokotseha ha tlhahiso ea metsi a senyang, lefu la lupus-like, alopecia;
• Ho phatloha ha letlalo, dermatosis, ho hlohlona, bronchospasm, erythema.

Lipontšo tsa ho feta tekano

Matšoao a ho feta tekano le lithethefatsi tseo ho nahanoang ka tsona ke li-nausea, gastralgia, ho hlatsa, ho otsela le ho fokola. Bakeng sa ho felisoa ha bona, ho hlajoa ke gastric ho hlajoa, ho laxative le phekolo ea matšoao.

Ho lumellana le lisebelisoa tse ling

Meriana "Mesakol" e fokotsa ketso ea "Spironolactone", "Furosemide", "Rifampicin" le sulfonamides. E boetse e eketsa liphello tsa hypoglycemic tsa li-derivatives tsa sulfonylurea, chefo ea methotrexate le ulcerogenicity ea GCS.

Hape hoa lokela ho hlokomeloa hore meriana ena e liehisa motsoako oa cyanocobalamin, hape e eketsa phello ea li-agent tse ling tsa motlakase (ke hore, li-blockers tse thibelang likokoana-hloko) le ho eketsa phello ea li-anticoagulants.

Litlhahiso tse Khethehileng

• Letšollo le hlahang ka phekolo ea Mesakol hase kamehla liphello tsa meriana. Boemo bona bo ka ba pontšo ea lefu le leholo.
• Ha u noa meriana ena, u lokela ho etsa tlhahlobo ea mali le tlhahlobo ea moroto kamehla.
• Haeba tefello e ne e lahliloe, e latelang e lokela ho nkoa ka nako efe kapa efe.
• Nakong ea phekolo le meriana ena, moro oa mokuli le teardrop li ka etsoa ka 'mala oa mosehla-mosehla.

Mesakol: li tšoanang le litšenyehelo

U ka nkela meriana ena sebaka ka lisebelisoa tse kang Salazopyridazine, 5-ASA, Tidokol, Asakol, Samezil, Salofalk, Mesalazin, Salosinal, Pentasa.

Matlapa a Mesakol ke bokae? Theko ea moriana ona ke li-ruble 600-680 (lipilisi tse 50).

Tlhahlobo ea bareki

Bakuli ba tlohela litlhaloso tse fapaneng haholo tsa Mesakol. Ba bang ba bona ba tlaleha hore meriana ena e atleha ho tšoara maloetse a mala a mala. Ba bang ba pheha khang ea hore lipilisi tsena ha li na thuso. Ka hona, ho ka phethoa ka mokhoa o sireletsehileng hore "Mesakol" e na le phello e fapaneng ho bakuli ba fapaneng.

Tsela e kholo ea lithethefatsi ena ke ho ba teng ha palo e kholo ea li-contraindications le liphello tse bohloko.