From seo thusa "Nise" (matlapa)? Litaelo tsa tšebeliso, analogs

Na u se u tseba seo etsang "Nise" (matlapa)? Haeba boitsebiso bo joalo ha u na, joale re tla hlahisa e thepa ea sehlooho sena.

Ambalaji sehlahiswa le sebopeho lona

The ha e le hantle ba le etsa hore "Nise" (matlapa), re hlalosa mona ka tlase. The a sebetsang a motsoako ka lithethefatsi ena ke nimesulide. Hape le ka sebopeho, ho kenyeletsa le dikarolo tse kang microcrystalline selulose, aspartame, k'halsiamo phosphate, colloidal silicon e dioxide, starch poone, magnesium stearate, sodium carboxymethyl starch, talc le phaenapole tatso.

Ka rekisa nkoa moriana o ho machachetsi matlapa 10, tletse ka mabokoseng lebokoso.

Molao-motheo oa ketso ea moriana

Pele re araba potso ea hore na o etsa hore "Nise" (matlapa), o lokela ho re bolella hore na ba sebelisa lithethefatsi kapa ea sebetsang ho.

Ho ea ka litaelo tseo, ho NSAIDs hore khetha thibela Cox-2, e le hore ke potlakisang tsebetso ea lik'hemik'hale ho akarelletsa tswakana tsa prostaglandins - mediators la bohloko, ho ruruha le edema. thepa Ho feta moo-ba khahlanong le a hlabang, ho nkoa hore lithethefatsi lipontsuoa analgesic le bohato antipyretic.

Re ke ke ra bolela hore lithethefatsi thibela (e reversible) sebopeho sa prostaglandin E2 ka nyolohela litseleng nociceptive tsamaiso e khopo le sebaka sa ho ruruha, hammoho le ka litsela tsa conduction la litakatso (bohloko) a khoele lesapo la mokokotlo.

Ho lokisetsa "Naiz" analogs tse ho tse thathamisitsoeng ka tlaase mona, ho fokotsa ea mahloriso ea prostaglandin H2 (-ba ea nakoana), e leng, le tlas'a tšusumetso ea prostaglandin isomerase, ho na le prostaglandin E2. Fokotsa tsa mahloriso tsa itlhomme bobeli ho ea fokotseha ka tekanyo e sa Tshebediso ya ya receptor-mofuta ER (prostanoid), e leng e bontšoa ka litla a hlabang le analgesic.

Ho e boetse e lokela ho hlokomeloe hore ho na le tse sa reng letho isa tekanyong ea lithethefatsi ama motho e nkoa e le oa Cox-1. Tlas'a maemo a fisioloji, ho hang thibela prostaglandin E2 tloha acid e arachidonic. Sena se fokotsang palo ea bohloko lithethefatsi liketsahalo.

The thepa ka sehloohong sa moriana (NSAID)

Ho lokisetsa "Naiz" kgona ho thibela metsoako platelet aggregation. Hlahellang ke inhibiting le tswakana tsa thromboxane A2 le endoperoxides. Ho phaella moo, ho patelang batho histamine ho lokolloa thulaganyong, le hape ho fokotsa tekanyo ea ho bronchoconstriction, e neng e bakoa ke ho pepesehela acetaldehyde le histamine.

Ditsebi ba pakile hore nimesulide ntle thibela ho tswakana tsa urokinase le IL-6, ho thibela ka ho timetsoa ha lefufuru. Ho feta moo, ho thibela ho tswakana tsa metalloproteases, ho thibela ka ho timetsoa ha collagen le proteoglycans.

Ho ea ka litaelo tseo, ka ho fokotsa mosebetsi oa myeloperoxidase tlas'a ho nahanela lithethefatsi hlahisa antioxidant thepa le thibela sebopeho sa dihlahiswa (chefo) bola O _2. E le sebedisana ka le receptors le glucocorticoid le activates bona, e leng thusa hore ho ea bohato-ba khahlanong le a hlabang.

The kinetics ea lithethefatsi

Mora analgesic molomo "Nise" e ananelang tloha intestine le. Lijo ho noa ho fokotsa tekanyo ea absorption ea lithethefatsi, empa ha e ame isa tekanyong eona.

maemo tlhōrō mali a nimesulide fihlellwa ka mor'a lihora tse 2,6. mokgatlo lona le protheine e fihla 95%.

lithethefatsi ena le kenella ka hare ka lisele tsohle motšehali feditsweng. Ho feta moo, e fumanoa ka asiti mahareng tsepamiso ho ruruha le mokelikeli mokelikeling.

Nimesulide metabolism ka sebete. Lona halofo bophelo bo lihora tse 5. O ile a bontša ka ho liphio, hammoho le 'moho le bile.

Ho bonahala ho lozenges

From seo thusa "Nise" (matlapa)? Tsa chelete e beuweng for:

• sciatica, ramatiki, sciatica;
• lumbago, tabanan, articular lefu, lefu rheumatic le gout exacerbation;
• psoriatic ramatiki, arthralgia, ankylosing spondylitis;
• ramatiki ea tšimoloho e sa tšoaneng, osteochondrosis le lefu radicular;
• ho ruruha ha ligaments, myalgia, rheumatic le ruruhisang hlahang ho yona, bursitis, ho ruruha ha tendons ea;

• bohloko syndromes se hlahang ho yona fapaneng (ho akarelletsa le ho sithabela, postoperative, leino, algodismenoree, hlooho e opang);
• inflammations ea tsamaiso ea musculoskeletal le dinama tse nyenyane tse le bonolo.

Ho lokela ho hlokomeloe hore hantle ho "Nise" mocheso. lithethefatsi ena e sebelisoa ka feberu se hlahang ho yona fapaneng, ho akarelletsa le mafu a hlabang le a tšoaetsanoang.

Contraindications NSAIDs

Lithethefatsi "Nise" thibetsoe thonya bokhachane. Hape, ha hoa lokela ho sebelisoa:

• "Aspirini rapeloang ka boraro";
• erosive le diso ulcerative tsa pampitšana gastrointestinal (ka exacerbation);
• kanyeso;
• tsoa mali ho tswa ho pampitšana gastrointestinal;
• phytoteratology sebete mosebetsi;
• ka bana ho fihlela ho lilemo tse peli;
• matla renal insufficiency;
• giperuvstvitelnosti.

Ba hlokolosi khethehileng moemeli ena tseo ke li behetsoeng mofuta lefu la tsoekere mellitus, kgatelelo ya madi le insufficiency cardiac.

Mokhoa oa ho nka "Nise"?

O ne a nka meriana ka mokgwa wa matlapa laetsoeng ka hare feela. bakuli ba batho ba baholo e kgothaletswa ho nka 100 mg, ka makhetlo a mabeli ka letsatsi. The litekanyetso li behoa palo e kahodimodimo ea lithethefatsi ka ho ya ka letsatsi le ke 400 mg,.

Mabapi le matlapa dispersible Joale, pele a etsa moriana o joalo, e lokela ho pele e neng e qhalwa ho ya ka 5 di ml metsi tlwaelehileng (1 lijo tse theolelang khaba). Ho chesa sesebelisoa li tlameha qetellong ea lijo kapa ka mor'a lijo.

Bana ba lithethefatsi matlapa a sa ba laela. Bakeng sa bona, ho na le mofuta o mong oa lithethefatsi - ka ho fanyeha. E kgothaletswa ho nka ka ba lilemo li peli.

lehlakoreng liketsahalo

Ho lokisetsa "Naiz", le litekanyetso li behoa ea eo e ne e hlahisoa ka holimo e ka etsa hore liphetoho tse sa lakatseheng tse kang:

• lesokolla, sa foleng lefu la sebete, ho nyekoa ke pelo, khaello ea mali, ho hlatsa;
• agranulocytosis, bohloko ka mpeng, khaello ea mali, letšollo, leukopenia;
• erosive le diso ulcerative tsa pampitšana gastrointestinal, hlooho e opang, ho eketseha ha transaminases sebete;
• anaphylactic makala, molikoalikoane, ho letlalo lekhopho;
• prolongation ea tsoa mali nako, bronchospasm, hematuria, mokelikeli tshegetsa le go tlotla.

maemo a ho overdose

Seo le matšoao a ho etsahala'ng ha fumana palo e khōlō ea "Nise" matlapa? The litekanyetso li behoa ea phekolo ena lokela ho ikemisetsa ka ho ngaka ho ba teng. Tabeng ea a e-ja ka phoso ea lithethefatsi (ka ngata), mokuli a ka ba le matšoao a latelang: tsitsipana, e ile ea eketseha khatello ea mali, ho teneha tsa pampitšana gastrointestinal, liphio mosebetsi phytoteratology, ho hloleha sebete, le ho tepella maikutlo ho hema.

Ho felisa e re jwalo hlatsoa mala le mamello, butswe mashala le phekolo bontshang matshwao.

ditshebeditsano lithethefatsi

Le tsoa hong preroralnom baeti ba fihlelang ho lokisetsa "Naiz" diuretics "Digoxin" "phenytoin", antihypertensive mahlahana le mahlahana lithium, hammoho le tse ling tse NSAID, cyclosporine, anticoagulants, methotrexate, meriana hypoglycemic (molomo), mokuli a ka bontša ditshebeditsano lithethefatsi (ho tloha ka -this mahlahana tsena phehisana bakeng sa tlama le liprotheine).

Lithethefatsi "Nise": analogs le ulasan pelanggan

Nka sebaka sesebelisoa ka nkoa meriana tse kang "nimulid", "holim'a", "Arcoxia", "Mesulid", "meloxicam", "Nimesil", "Movalis" "nimesulide" "Denebola", "Niemiec".

Boholo ba ulasan pelanggan mosebedisi ka paakanyong joale ke boikutlo bo botle. Ho ea ka bona, ho felisa ka potlako "Nise" bohloko, lithethefatsi le boetse le sebelisoa ka haholo e atlehang -ba khahlanong le a hlabang moemeli. Le hoja ba bang bakuli ba bolela hore lithethefatsi ena e na le e 'ngoe drawback khōlō. Ke hangata haholo baka liphetoho lehlakoreng kang mathata molikoalikoane, ho fokola le tsamaiso tshilong ya dijo. Tabeng ena, lingaka li khothalletsa ho tlosa lithethefatsi tšoanang.