Electrophoresis liprotheine mali

Liprotheine tse likarolo senotlolo liseleng tsohle le lisele. Di thehoa ka liketane tsa amino acid. Ka batho, ho na le tse fetang 100 mefuta e sa limolek'hule tsa protheine. Kaofela ha bona ba hlokomela mefuta e fapaneng ya mesebetsi. Har'a limolek'hule le thōko fibrinogen transferrin, immunoglobulins, lipoproteins, albumin, 'me ba bang. Ho itšehla thajana ea likaroloana tsa protheine ka litsela tse sa tšoaneng, empa ka ho fetisisa ratoa fumanweng electrophoresis. Tšohla lintlha tsa lona ka ho qaqileng.

Overview

Kakaretso ea liprotheine mali theha "palo yohle protheine". E, le eena, ho akarelletsa ho dikarolo tse kang albumin le globulin. разделяет их на эти элементы. Electrophoresis liprotheine mali a arola ba kenya likarolo tsena. Mokhoa ona e ileng ea nolofalletsa karohano ho tlisa tlhathoba ho boemong ba se tlang.

khethehileng

. Limolek'hule fumana mpe kapa positive, qoso, hore itšetlehile ka tikoloho eo ho eona electrophoresis e phethile likaroloana tsa mali protheine. Ka mokhatlo oa bona e ama chelete ea tefo. Tlhaku mokhatlo oa ikemiselitse le sebopeho le boholo ba limolek'hule bona, boima ba 'mele ea bona. Likarolo ka qoso positive, ba le adsorption molemo ho feta negative.

albumin

Ba li nkoa e kholo ka ho fetisisa limolek'hule protheine har'a lihlopha tsohle serum ka. palo ea bontša boemo protheine albumin litho tse ngata ka hare. E le e 'ngoe ea maikemisetso le senotlolo sa limolek'hule se sebetsa joaloka bolokoe colloidal osmotic khatello. Ho thusa 'ne tsamaiso mokelikeli ka maling. Ka lebaka leo, ho ka etsahala hore a hlalose ntshetsopele ya maemo pathological kang edema methapo, ascites, 'me joalo-joalo.

globulin

Di arotsoe ka lihlopha tse 'maloa. позволяет провести их количественное разделение в лаборатории. Protein electrophoresis mokhoa o dumella ho phetha karohano bona ditirisanommogo ka laboratori ea. Har'a metsoako ea globulin le thōko:

1. Alpha-1. likarolo tsena di na le dipegelo, alpha-1-antitrypsin, le thyroxine tlamang globulin.
2. Alpha-2. Ba na le likarolo tse ling tsa ceruloplasmin, haptoglobin le ba bang.
3. Beta-likarolo. Har'a bona ba metsoako e ea tlatsana le, transferrin, beta-lipoprotein.
4. Ea gamma karolo. E na le immunoglobulins A, E, F, G, D.

с увеличением частей альфа-1 и альфа-2 указывает на начало воспалительного процесса. Electrophoresis liprotheine le eketsehileng likarolo alpha-1 le, alpha-2 e bontša qala ho ea ho ruruha.

ntho e tloaelehileng

Electrophoresis liprotheine bonahatsa bophelo bo botle phelang latelang (ka g, / legal dl):

1. Albumin 3.4-5.
2. Alpha 1 globulin - ho tloha 0,1 ho 0,3.
3. Alpha-2 - ho tloha 0.6 ho 1.
4. Beta-globulin - ho tloha ho 0.7 ho 1.2.
5. Ea gamma globulin - ho tloha ho 0.7 ho 1,6.
6. litsupa akaretsang - ho tloha 6,4 ho 8,3.

menyetla ya fumanoe

Joalokaha ho ne ho itse ka holimo, le sebelisitsoe ka moriana karohano lekana mekhoa ea limolek'hule protheine ka dihlahlobo tse itseng. Leha ho le joalo, e tloaelehileng haholo ke electrophoresis liprotheine. фракции, содержащиеся в определенных биологических средах, могут выделяться только этим способом. Protein dikotwana tse libakeng tse itseng tsa likokoana-hloko a ka feela ho abelwa ka tsela ena. Ka ho khetheha, e lumella u ho fumana paraproteins. специальный клинический способ анализа. Protein electrophoresis - le mokhoa o khethehileng oa and analysis litleleniki tsa. Ho thusa ho lemoha liphetoho leha e le efe limolek'hule, e leng ka sebeletsa e le matšoao a pathologies itseng. – доступный способ диагностики. Electrophoresis protheine dikotwana - tsela e ka theko e tlaase ho fumanoe. A li entseng ka dilaboratiriamong tsohle. E le melemo undoubted e lokela ho e mong ea bitsoang ho nepahala le lebelo la sephetho fumana. позволяет выявить изменения: Electrophoresis liprotheine serum senola liphetoho tse:

1. Ka sebopeho sa limolek'hule tsa protheine.
2. The karo-karolelano ditirisanommogo ea thepa ea motheo mehaho.

Diphetho tsa ho etsa lipatlisiso le

Capillary electrophoresis dumella ho senola mefuta e meng ea liprotheine. Leha ho le joalo, ba bang ba limolek'hule le ke keng la lemoha ka mokhoa ona. Kantle ke albumin. Bakeng sa and analysis tebileng tsa likaroloana tsa sebelisoa electrophoresis. Boemo ba lihlopha tse sa tšoaneng e ka lekanyetsoa ka palo ea palo yohle liprotheine index ea eketseha ke a lekanyelitsoeng lekana% ka mong.

makolopetso

обязательно должен выполняться одновременно с измерением содержания иммуноглобулинов М, А и G. Варианты с большей концентрацией первых двух, которые не могут отдельно исследоваться, необходимо направить на повторный анализ. Electrophoresis liprotheine lokela ho ho phethwa ka nako ka tekanyo ea immunoglobulins M, A le G. variants le mahloriso e phahameng tsa pele tse peli tse, e leng ke ke a hlahloba ka thoko, ho ke ke ho hlokahala ho romela ho botjha hlahlojoe. Hoa hlokahala ho qhelela ka thōko lihlopha tse nyenyane immunofixation paraproteinovyh.

setshwantsho ea tleleniki

позволяет обнаружить начало течения патологий почек и печени, генетические деформации, формирование опухолей злокачественного характера, активацию хронических и острых инфекций. Electrophoresis liprotheine dumella ho lemoha qala ho ea phallo pathologies liphio le sebete, khatello le liphatsa tsa lefutso, sebopeho sa bolaeang lihlahala tlhaku Tshebediso ya a sa foleng le a tsoaetsanang a hlobaetsang. Ka mokhoa ona, e totobatsa 'maloa a "syndromes", eo e bontša decoding tsa and analysis ho:

1. Eketseha palo ea, alpha-1 le, alpha-2 globulin, fibrinogen C-arabelang protheine, hammoho le a mangata a liprotheine hlobaetsang-mohato bontša ho qaleha ha e hlobaetsang ruruha le Tshebediso ya ea tsamaiso motlatsi. Ha re khanna ka hematology and analysis e bonolo ka ba boemong bona e tla senoloa feela eketseha ESR le leukocytosis.
2. Fokotseha ea mahloriso ka ho feletseng ea albumin bontša lefu haholo sebete. Foleng lefu la sebete le ho thatafala ha sebete etsahala'ng ha chelete tsa gamma-globulin. показывает их превышение над альбуминами, необходимо незамедлительно повторить исследование и направиться на комплексное обследование. Ha protheine electrophoresis bontša feteletseng bona holim'a albumin, le tlhokahalo e potlakileng ho pheta thuto le hlooho ho tlhlahlobo le akaretsang.
3. A keketseho e itekanetseng ea beta-, gamma- le Alpha-2-globulin le ea fokotseha hanyenyane ka albumin bontša collagenoses, ho ruruha foleng, malignancy neoplasms nang kotsi tlhaho, kulisa, autoimmune pathologies.

lefu nephrotic

O fumanoa ha decoding lithuto bontšang ho eketseha ha boemo ba karaoke set ea limolek'hule le protheine ea tubules le renal le proteinuria khetha. Ea bobeli ke palo e khōlō ea excretion albumin, 'me e nyenyane ea tlaase globulin limolek'hule boima ka moroto wa. Hammoho le letotong la lefu e fumana matla tswakana ea limolek'hule kholo sehlopha alpha-2-globulin ka sebete. Ba ipokellela ka mokelikeli mali. Ntlheng ena, tse kang mohlala e thehoa. Decreases albumin, le eketsa ka tjhelete e ya, alpha-2-globulin.

Ho phaella moo

tahlehelo bohlokoa protheine ha ba koalloa lefu nephrotic. Di tšoauoa le Laella lefu, chesa a pharaletseng a pathologies ea tsamaiso tshilong ya dijo le tse ling tse joalo. Ha Abuse gastrointestinal proteinogram decoding bontša ea fokotseha ya dikahare albumin le keketseho tsoa hong ka etsang liphesente tse lihlopha tsohle globulin. Ho laola boemo protheine ka finyelloang ke kamehla tshebetso electrophoresis. Ho expedient ho hlahisa lithethefatsi, likarolo protheine Phetolo. Ka tshwaileng e fokotseha ka ea gamma-globulin ba fumanoa immunodeficiency haholo fumanweng kapa mofuta congenital. Maemong a joalo, ho tseba hore na Bibele e feletseng ea litleleniki tsa setšoantšong se ka ho eketsehileng kgothaletswa ho beha dikahare tsa immunoglobulin M, A, G.

paraproteinemia

Electrophoresis e nahana ka tsela eo feela e lumellang ho lemoha. Paraproteinemia - letšoao tsamaeang le bo tsoelang pele e hlahala kgolo ya nang kotsi le se bolaeang tlhaho. Bokella maling a lisireletsi monoclonal hammoho le likhechana tsa likamano tsa bona le tšekamelo ea ho myeloma multiple le leukemias itseng. Bakeng sa ho khethollo ea 'me ho thehoa ha liketane paraprotein protheine e kgothaletswa ho etsa electrophoresis fetotsoeng - immunofixation. Ho khanna thuto ea ho sebedisa tse kang helium poleiti le antiserum.

Litšobotsi tse dikotwana ho mothinya electrophoretic

1. Transthyretin (prealbumin). Ho emela protheine renal. Ho e teng tlasa albumin, fapaneng nakoana halofo bophelo. Prealbumin tlama thyroid li-hormone lipalangoang protheine bakeng vithamine A. dikahare lona re lumella hore re ho sekaseka phepelo ea liprotheine tsa lisele pheriferale. Ka khaello ea lefu phepo e nepahetseng le sebete ho na le ea fokotseha ka bolelelane lona.
2. Alpha-1-lipoproteins. Li emela junifomo faintly sebakeng pakeng tsa, alpha-1-globulin le albumin. Litekanyo tsa libaka pele li hlalosoa ke boemo ba likarolo tse ling. Ka ho khetheha, e, alpha-1- antitrypsin, -fetoprotein, -microglobulin. Ka ho ruruha a hlobaetsang le ho boletsoe bonahalang ntshofala.
3. Alpha-1 antitrypsin. a iponahatsa lona liphatsa tsa lefutso ke iponahatsang phetoho mokhatlo oa lihaha-'mele, phahameng liteko sebete mosebetsi, ho thatafala ha sebete. Khahlanong le semelo sa ho ima tšoauoa fokotseha.
4. Alpha-1-fetoprotein. Ke lesupa tsa pathologies e amanang le sebete le lihlahala congenital ka tepelletse maikutlong prenatal.
5. Ea gamma-globulin. Zone e tšoauoa ka ho beha thepa ea litlelase immunoglobulin M le G.
6. Fibrinogen. O ke protheine tsamaisong ea mali hoama. Located pakeng tsa ea gamma le tsa beta globulin. Ka ho ruruha a hlobaetsang le a hlokomela keketseho ea fibrinogen. Ka ho hloleha haholo sebete, disseminated intravascular coagulation senola ea fokotseha ka boemo ba lona.

immunoglobulins Monoclonal li fumanoa feela ka ho ba teng ha malwetse.